Meno Produktu :Kalcitonínový losos
Obchodné meno:Saleton's
CAS č.:47931-85-1
Molekulárny vzorec: C145H240N44O48S2
Molekulová hmotnosť:3431.85g/mol
Čistota : 98% HPLC
Vzhľad: Lyofilizovaný prášok
Typické použitie:Liečba osteoporózy
kalcitonín (salmon) is an hypocalcemic hormone produced by the parafollicular C cells of the thyroid or by the ultimobranchial bodies of nonmammalian vertebrates. Calcitonin decreases blood calcium and phosphate due to inhibition of resorption by osteoblasts and osteocytes. Calcitonin contains a single disulfide bond, which causes the amino terminus to assume the shape of a ring. Alternative splicing of the calcitonin pre-mRNA can yield a mRNA encoding calcitonin gene-related peptide; that peptide appears to function in the nervous and vascular systems. The calcitonin receptor has been cloned and shown to be a member of the seven-transmembrane, G protein-coupled receptor family.
-Treatment of postmenopausal women with osteoporosis at high risk for fracture
-Increase of bone mass in men with primary or hypogonadal osteoporosis at high risk for fracture
-Treatment of men and women with osteoporosis associated with sustained systemic glucocorticoid therapy at high risk for fracture
| Položka |
Štandardné |
Výsledky testu |
| Identifikácia |
A.H-NMR:Comply with the structure |
Vyhovuje |
|
B.LC-MS:Comply with the structure |
Vyhovuje |
|
C.The IR spectrum of sample should be identical with that of reference standard; |
Vyhovuje |
|
D.HPLC-ESI-MS
The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation, as obtained in the Assay. |
Vyhovuje |
| Crystallinity |
spĺňa požiadavky. |
Vyhovuje |
| Strata sušením |
≤ 2,0 % |
0.19% |
| Ťažké kovy |
≤10 ppm |
<10ppm |
| Voda |
≤ 1,0 % |
0.1% |
| Sulphated ash |
≤ 0,5 %, determined on 1.0 g. |
0.009% |
| Príbuzné látky |
Unspecified impurities: for each impurity |
<0.10% |
|
Total Impurity |
0.18% |
| Čistota |
≥99,0 % |
99.7% |
| Skúška |
99.0%~101.0% (anhydrous substance). |
99.8% |
| Microbiological Analysis |
|
|
| Total plate count |
≤ 1000 cfu/g |
Vyhovuje |
| Yeast and Moulds |
≤ 100 cfu/g |
Vyhovuje |
| E. Coli. |
Absent |
Negatívne |
| Salmonella |
Absent |
Negatívne |
| S.aureus |
Absent |
Negatívne |
| Skladovanie |
Preserve in well-closed, light-resistant and airtight containers. |
Vyhovuje |
