nombre del producto :salmón calcitonina
Nombre comercial:de Saleton
No CAS.:47931-85-1
Fórmula molecular: C145H240N44O48S2
Peso molecular:3431.85g/mol
Pureza : 98% HPLC
Apariencia: Polvo liofilizado
Uso típico:Tratamiento de la Osteoporosis
calcitonina (salmon) is an hypocalcemic hormone produced by the parafollicular C cells of the thyroid or by the ultimobranchial bodies of nonmammalian vertebrates. Calcitonin decreases blood calcium and phosphate due to inhibition of resorption by osteoblasts and osteocytes. Calcitonin contains a single disulfide bond, which causes the amino terminus to assume the shape of a ring. Alternative splicing of the calcitonin pre-mRNA can yield a mRNA encoding calcitonin gene-related peptide; that peptide appears to function in the nervous and vascular systems. The calcitonin receptor has been cloned and shown to be a member of the seven-transmembrane, G protein-coupled receptor family.
-Treatment of postmenopausal women with osteoporosis at high risk for fracture
-Increase of bone mass in men with primary or hypogonadal osteoporosis at high risk for fracture
-Treatment of men and women with osteoporosis associated with sustained systemic glucocorticoid therapy at high risk for fracture
| Item |
Standard |
Test Results |
| Identificación |
A.H-NMR:Comply with the structure |
Cumple |
|
B.LC-MS:Comply with the structure |
Cumple |
|
C.The IR spectrum of sample should be identical with that of reference standard; |
Cumple |
|
D.HPLC-ESI-MS
The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation, as obtained in the Assay. |
Cumple |
| Crystallinity |
meets the requirements. |
Cumple |
| Pérdida por secado |
≤2.0% |
0.19% |
| Heavy metals |
≤10 ppm |
<10ppm |
| Agua |
≤1,0% |
0.1% |
| Cenizas sulfatadas |
≤0.5%, determined on 1.0 gramo. |
0.009% |
| Related substances |
Unspecified impurities: for each impurity |
<0.10% |
|
Total Impurity |
0.18% |
| Pureza |
≥99,0% |
99.7% |
| Ensayo |
99.0%~101.0% (anhydrous substance). |
99.8% |
| Microbiological Analysis |
|
|
| Total plate count |
≤1000ufc/g |
Cumple |
| Yeast and Moulds |
≤100cfu/g |
Cumple |
| mi. Coli. |
Absent |
Negative |
| Salmonella |
Absent |
Negative |
| S.aureus |
Absent |
Negative |
| Almacenamiento |
Preserve in well-closed, light-resistant and airtight containers. |
Cumple |
