Nom du produit :Calcitonine de saumon
Nom commercial:de Saleton
N ° CAS.:47931-85-1
Formule moléculaire: C145H240N44O48S2
Masse moléculaire:3431.85g/mole
Pureté : 98% CLHP
Apparence: Poudre lyophilisée
Utilisation typique:Traitement de l'ostéoporose
Calcitonine (salmon) is an hypocalcemic hormone produced by the parafollicular C cells of the thyroid or by the ultimobranchial bodies of nonmammalian vertebrates. Calcitonin decreases blood calcium and phosphate due to inhibition of resorption by osteoblasts and osteocytes. Calcitonin contains a single disulfide bond, which causes the amino terminus to assume the shape of a ring. Alternative splicing of the calcitonin pre-mRNA can yield a mRNA encoding calcitonin gene-related peptide; that peptide appears to function in the nervous and vascular systems. The calcitonin receptor has been cloned and shown to be a member of the seven-transmembrane, G protein-coupled receptor family.
-Treatment of postmenopausal women with osteoporosis at high risk for fracture
-Increase of bone mass in men with primary or hypogonadal osteoporosis at high risk for fracture
-Treatment of men and women with osteoporosis associated with sustained systemic glucocorticoid therapy at high risk for fracture
| Article |
Standard |
Résultats de test |
| Identification |
A.H-NMR:Comply with the structure |
Conforme |
|
B.LC-MS:Comply with the structure |
Conforme |
|
C.The IR spectrum of sample should be identical with that of reference standard; |
Conforme |
|
D.HPLC-ESI-MS
The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation, as obtained in the Assay. |
Conforme |
| Crystallinity |
meets the requirements. |
Conforme |
| Perte au séchage |
≤2.0% |
0.19% |
| Métaux lourds |
≤10 ppm |
<10ppm |
| Eau |
≤1,0% |
0.1% |
| Cendres sulfatées |
≤0,5 %, déterminé sur 1.0 g. |
0.009% |
| Substances apparentées |
Impuretés non précisées: pour chaque impureté |
<0.10% |
|
Impureté totale |
0.18% |
| Pureté |
≥99,0 % |
99.7% |
| Essai |
99.0%~101,0% (substance anhydre). |
99.8% |
| Analyse microbiologique |
|
|
| Nombre total de plaques |
≤1000ufc/g |
Conforme |
| Yeast and Moulds |
≤100ufc/g |
Conforme |
| E. Coli. |
Absent |
Négatif |
| Salmonelle |
Absent |
Négatif |
| S.aureus |
Absent |
Négatif |
| Stockage |
Conserver dans un endroit bien fermé, contenants résistants à la lumière et hermétiques. |
Conforme |
