Produktnavn :Kalsitonin laks
Handelsnavn:Saleton sin
CAS-nr.:47931-85-1
Molekylær formel: C145H240N44O48S2
Molekylær vekt:3431.85g/mol
Renhet : 98% HPLC
Utseende: Lyofilisert pulver
Typisk bruk:Behandling av osteoporose
Kalsitonin (salmon) is an hypocalcemic hormone produced by the parafollicular C cells of the thyroid or by the ultimobranchial bodies of nonmammalian vertebrates. Calcitonin decreases blood calcium and phosphate due to inhibition of resorption by osteoblasts and osteocytes. Calcitonin contains a single disulfide bond, which causes the amino terminus to assume the shape of a ring. Alternative splicing of the calcitonin pre-mRNA can yield a mRNA encoding calcitonin gene-related peptide; that peptide appears to function in the nervous and vascular systems. The calcitonin receptor has been cloned and shown to be a member of the seven-transmembrane, G protein-coupled receptor family.
-Treatment of postmenopausal women with osteoporosis at high risk for fracture
-Increase of bone mass in men with primary or hypogonadal osteoporosis at high risk for fracture
-Treatment of men and women with osteoporosis associated with sustained systemic glucocorticoid therapy at high risk for fracture
| Punkt |
Standard |
Testresultater |
| Identifikasjon |
A.H-NMR:Comply with the structure |
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B.LC-MS:Comply with the structure |
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C.The IR spectrum of sample should be identical with that of reference standard; |
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D.HPLC-ESI-MS
The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation, as obtained in the Assay. |
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| Crystallinity |
meets the requirements. |
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| Tap ved tørking |
≤2,0 % |
0.19% |
| Tungmetaller |
≤10 ppm |
<10ppm |
| Vann |
≤1,0 % |
0.1% |
| Sulphated ash |
≤0,5 %, determined on 1.0 g. |
0.009% |
| Relaterte substanser |
Unspecified impurities: for each impurity |
<0.10% |
|
Total urenhet |
0.18% |
| Renhet |
≥99,0 % |
99.7% |
| Assay |
99.0%~101,0 % (anhydrous substance). |
99.8% |
| Microbiological Analysis |
|
|
| Total plate count |
≤1000 cfu/g |
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| Yeast and Moulds |
≤100cfu/g |
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| E. Coli. |
Absent |
Negativ |
| Salmonella |
Absent |
Negativ |
| S.aureus |
Absent |
Negativ |
| Oppbevaring |
Preserve in well-closed, light-resistant and airtight containers. |
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