商品名 :サーモンカルシトニン
商標名:セールトンズ
CAS番号:47931-85-1
分子式: C145H240N44O48S2
分子量:3431.85グラム/モル
純度 : 98% HPLC
外観: 凍結乾燥粉末
典型的な使用:骨粗鬆症の治療
カルシトニン (salmon) is an hypocalcemic hormone produced by the parafollicular C cells of the thyroid or by the ultimobranchial bodies of nonmammalian vertebrates. Calcitonin decreases blood calcium and phosphate due to inhibition of resorption by osteoblasts and osteocytes. Calcitonin contains a single disulfide bond, which causes the amino terminus to assume the shape of a ring. Alternative splicing of the calcitonin pre-mRNA can yield a mRNA encoding calcitonin gene-related peptide; that peptide appears to function in the nervous and vascular systems. The calcitonin receptor has been cloned and shown to be a member of the seven-transmembrane, G protein-coupled receptor family.
-Treatment of postmenopausal women with osteoporosis at high risk for fracture
-Increase of bone mass in men with primary or hypogonadal osteoporosis at high risk for fracture
-Treatment of men and women with osteoporosis associated with sustained systemic glucocorticoid therapy at high risk for fracture
| Item |
標準 |
Test Results |
| 識別 |
A.H-NMR:Comply with the structure |
準拠 |
|
B.LC-MS:Comply with the structure |
準拠 |
|
C.The IR spectrum of sample should be identical with that of reference standard; |
準拠 |
|
D.HPLC-ESI-MS
The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation, as obtained in the Assay. |
準拠 |
| Crystallinity |
meets the requirements. |
準拠 |
| 乾燥減量 |
≤2.0% |
0.19% |
| ヘビーメタル |
≤10 ppm |
<10ppm |
| 水 |
≤1.0% |
0.1% |
| Sulphated ash |
≤0.5%, determined on 1.0 g. |
0.009% |
| 関連物質 |
Unspecified impurities: for each impurity |
<0.10% |
|
Total Impurity |
0.18% |
| 純度 |
≧99.0% |
99.7% |
| アッセイ |
99.0%~101.0% (anhydrous substance). |
99.8% |
| Microbiological Analysis |
|
|
| Total plate count |
≤1000cfu/g |
準拠 |
| Yeast and Moulds |
≤100cfu/g |
準拠 |
| え. Coli. |
Absent |
Negative |
| Salmonella |
Absent |
Negative |
| S.aureus |
Absent |
Negative |
| 保管所 |
Preserve in well-closed, light-resistant and airtight containers. |
準拠 |
