Nazwa produktu :Łosoś kalcytonina
Nazwa handlowa:Saleton
Nr CAS:47931-85-1
Formuła molekularna: C145H240N44O48S2
Waga molekularna:3431.85g/mol
Czystość : 98% HPLC
Wygląd zewnętrzny: Liofilizowany proszek
Typowe zastosowanie:Leczenie osteoporozy
Kalcytonina (salmon) is an hypocalcemic hormone produced by the parafollicular C cells of the thyroid or by the ultimobranchial bodies of nonmammalian vertebrates. Calcitonin decreases blood calcium and phosphate due to inhibition of resorption by osteoblasts and osteocytes. Calcitonin contains a single disulfide bond, which causes the amino terminus to assume the shape of a ring. Alternative splicing of the calcitonin pre-mRNA can yield a mRNA encoding calcitonin gene-related peptide; that peptide appears to function in the nervous and vascular systems. The calcitonin receptor has been cloned and shown to be a member of the seven-transmembrane, G protein-coupled receptor family.
-Treatment of postmenopausal women with osteoporosis at high risk for fracture
-Increase of bone mass in men with primary or hypogonadal osteoporosis at high risk for fracture
-Treatment of men and women with osteoporosis associated with sustained systemic glucocorticoid therapy at high risk for fracture
| Przedmiot |
Standard |
Wyniki testu |
| Identyfikacja |
A.H-NMR:Comply with the structure |
Zgodne |
|
B.LC-MS:Comply with the structure |
Zgodne |
|
C.The IR spectrum of sample should be identical with that of reference standard; |
Zgodne |
|
D.HPLC-ESI-MS
The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation, as obtained in the Assay. |
Zgodne |
| Crystallinity |
spełnia wymagania. |
Zgodne |
| Strata przy suszeniu |
≤2,0% |
0.19% |
| Metale ciężkie |
≤10 ppm |
<10ppm |
| Woda |
≤1,0% |
0.1% |
| Sulphated ash |
≤0,5%, determined on 1.0 g. |
0.009% |
| Substancje pokrewne |
Unspecified impurities: for each impurity |
<0.10% |
|
Całkowita nieczystość |
0.18% |
| Czystość |
≥99,0% |
99.7% |
| Analiza |
99.0%~101.0% (anhydrous substance). |
99.8% |
| Microbiological Analysis |
|
|
| Total plate count |
≤1000 jtk/g |
Zgodne |
| Yeast and Moulds |
≤100 jtk/g |
Zgodne |
| mi. coli. |
Absent |
Negatywny |
| Salmonella |
Absent |
Negatywny |
| S.aureus |
Absent |
Negatywny |
| Magazynowanie |
Preserve in well-closed, light-resistant and airtight containers. |
Zgodne |
