Cetrorelix acetát
Anglické synonymá: N-acetyl-3-(2-naftalenyl)-D-alanyl-4-chlór-D-fenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrozyl-N5-(aminokarbonyl)-D-ornityl-L-leucyl-L-arginyl-L-prolyl-D-alaninamid diacetát;Cetrorelix acetát;cetrorenlín acetát
CAS: 130143-01-0
Skúška: 98%
Molekulárny vzorec: C70H92N17O14
Molekulová hmotnosť:1551.16
Použitie: Je podporovať antagonistu receptora GnRH
Cetrorelix acetate is the acetic acid salt of cetrorelix. A gonadotrophin-releasing hormone (GnRH) antagonist, it is used for treatment of infertility and of hormone-sensitive cancers of the prostate and breast. It has a role as a GnRH antagonist and an antineoplastic agent. It is an oligopeptide and an acetate salt. It contains a cetrorelix.
The use of cetrorelix is contraindicated in severe renal impairment. It is not intended for women aged 65 years or older. Use in women with severe allergic conditions is not recommended. Use with caution in women with active allergies or history of allergies.
| Položky |
technické údaje |
Výsledky |
| Vzhľad |
Biely prášok |
Biely prášok |
| Identity by HPLC |
The retention is same with the reference substance |
Vyhovuje |
| Špecifická optická rotácia |
-20 to -30°(c=1,50%HAc) |
-26.5° |
| Aminokyselinové zloženie |
±20% of theoretical |
Vyhovuje |
| Čistota (pomocou HPLC) |
≥98,0 % |
99.11% |
| Súvisiaca látka(By HPLC) |
Celkové nečistoty(%)≤ 2,0 %
Largest Single Impurity(%)≤ 1,0 % |
0.89%
0.25% |
| Obsah acetátu (pomocou HPLC) |
≤ 15,0 % |
9.7% |
| Obsah vody (by Karl Fischer) |
≤ 10,0 % |
2.2% |
| Bakteriálne endotoxíny |
≤ 5 EU/mg |
Vyhovuje |
| Obsah peptidov(N %) |
≥85.0% |
86.5% |
