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Pharmaceutical Peptides

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  • COA

Cetrorelix acetate
English Synonyms: N-Acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N5-(aminocarbonyl)-D-ornithyl-L-leucyl-L-arginyl-L-prolyl-D-alaninamide diacetate;Cetrorelix acetate;Cetrorenlin Acetate
CAS: 130143-01-0
Assay: 98%
Molecular Formula: C70H92N17O14
Molecular Weight:1551.16
Usage: Is to promote the GnRH receptor antagonist

Cetrorelix acetate is the acetic acid salt of cetrorelix. A gonadotrophin-releasing hormone (GnRH) antagonist, it is used for treatment of infertility and of hormone-sensitive cancers of the prostate and breast. It has a role as a GnRH antagonist and an antineoplastic agent. It is an oligopeptide and an acetate salt. It contains a cetrorelix.

The use of cetrorelix is contraindicated in severe renal impairment. It is not intended for women aged 65 years or older. Use in women with severe allergic conditions is not recommended. Use with caution in women with active allergies or history of allergies.

Items Specifications Results
Appearance White powder White powder
Identity by HPLC The retention is same with the reference substance Conforms
Specific Optical Rotation -20 to -30°(c=1,50%HAc) -26.5°
Amino Acid Composition ±20% of theoretical Conforms
Purity (by HPLC) ≥98.0% 99.11%
Related Substance(By HPLC) Total Impurities(%)≤2.0%
Largest Single Impurity(%)≤1.0%
0.89%
0.25%
Acetate Content (by HPLC) ≤15.0% 9.7%
Water Content (by Karl Fischer) ≤10.0% 2.2%
Bacterial Endotoxins ≤5EU/mg Conforms
Peptide Content(N%) ≥85.0% 86.5%

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