Nome do Produto:Vapreotida,Octastatina,Vapreotida
Seqüência: D-Phe-[Cys-Tyr-D-Trp-Lys-Val-Cys]-Trp-NH2
Alias:Sanvar,RC-160;VAPREOTIDA;D-PHE-CYS-TYR-D-TRP-LYS-VAL-CYS-TRP-NH2; Octastatina;
FCYWKVCW-NH2;D-Phe-L-Cis(1)-L-Tir-D-Trp-L-Lis-L-Val-L-Cis(1)-L-Trp-NH2;
Nº de caixa: 103222-11-3
Fórmula molecular: C57H70N12O9S2
Peso molecular: 1131.40
Pureza (HPLC): 98.0%
Aparência: pó branco
Impureza Única(HPLC): 1.0%
Composição de Aminoácidos: 10% de teórico
Conteúdo Peptídeo(N%): 80%(por %N)
Teor de Água(Karl Fischer): 6.0%
Conteúdo de acetato(HPIC): 15.0%
Balanço de massa: 95.0~105,0%
Avaliar : Grau Farmacêutico
Armazenar: Fechadas, abaixo de 2 ~ 8℃ preservação
Uso : O medicamento pode ser usado para o tratamento de sangramento agudo precoce por varizes esofágicas (EVB) e terapia intervencionista endoscópica antes da hemostasia, também pode estar sangrando dentro 5 d lente para o tratamento e prevenção de recorrência após endoscopia. acetato de vapreotide será o único tratamento aprovado para sangramento de varizes esofágicas nos Estados Unidos.
Variceal bleeding is a life-threatening complication of portal hypertension. The recommended treatment includes the early administration of a vasoactive drug. Vapreotide is a somatostatin analogue with a different receptor affinity to octreotide. It decreases portal pressure and blood flow of collateral circulation in rats with cirrhosis. The pivotal study of early administration of vapreotide in patients with cirrhosis and variceal bleeding has shown a significant improvement in bleeding control and, in the subset of patients with significant bleeding, a significant reduction in mortality. In addition, a meta-analysis of four randomized studies has shown a significant improvement in bleeding control. Vapreotide administrated via the intravenous route is simple to use, with practically no contraindications and few, usually minor, side effects.
The immediate release formulation of Sanvar, a somatostatin analogue, is used in the treatment of acute esophageal variceal bleeding (EVB).Sanvar is used prior to endoscopic intervention to control haemorrhage and prevent re-bleeding during the critical five days following the onset of bleeding. EVB is a life threatening condition and the mortality rate is high (about 15% para 25%) in the first six weeks following the haemorrhage. EVB is the cause of about 70% of gastro-intestinal bleeding in patients suffering from liver cirrhosis.
