nome del prodotto:Vapreotide,ottastatina,Vapreotide
Sequenza: D-Phe-[Cys-Tyr-D-Trp-Lys-Val-Cys]-Trp-NH2
Alias:Sanvar,RC-160;VAPREOTIDE;D-PHE-CYS-TYR-D-TRP-LYS-VAL-CYS-TRP-NH2; ottastatina;
FCYWKVCW-NH2;D-Phe-L-Cys(1)-L-Tyr-D-Trp-L-Lys-L-Val-L-Cys(1)-L-Trp-NH2;
Cas n.: 103222-11-3
Formula molecolare: C57H70N12O9S2
Peso molecolare: 1131.40
Purezza (HPLC): 98.0%
Aspetto esteriore: polvere bianca
Singola impurità(HPLC): 1.0%
Composizione di amminoacidi: 10% di teorico
Contenuto peptidico(N%): 80%(di %N)
Contenuto di acqua(Karl Fischer): 6.0%
Contenuto in acetato(HPC): 15.0%
Bilancio di massa: 95.0~105,0%
Grado : Grado farmaceutico
Magazzinaggio: Chiuso, sotto 2 ~ 8 ℃ conservazione
Utilizzo : Il farmaco può essere utilizzato per il trattamento del sanguinamento acuto da varici esofagee precoce (EVB) e terapia interventistica endoscopica prima dell'emostasi, può anche sanguinare all'interno 5 d lente per il trattamento e la prevenzione delle recidive dopo endoscopica. Il vapreotide acetato sarà l'unico trattamento approvato per l'emorragia da varici esofagee negli Stati Uniti.
Variceal bleeding is a life-threatening complication of portal hypertension. The recommended treatment includes the early administration of a vasoactive drug. Vapreotide is a somatostatin analogue with a different receptor affinity to octreotide. It decreases portal pressure and blood flow of collateral circulation in rats with cirrhosis. The pivotal study of early administration of vapreotide in patients with cirrhosis and variceal bleeding has shown a significant improvement in bleeding control and, in the subset of patients with significant bleeding, a significant reduction in mortality. Inoltre, a meta-analysis of four randomized studies has shown a significant improvement in bleeding control. Vapreotide administrated via the intravenous route is simple to use, with practically no contraindications and few, usually minor, side effects.
The immediate release formulation of Sanvar, a somatostatin analogue, is used in the treatment of acute esophageal variceal bleeding (EVB).Sanvar is used prior to endoscopic intervention to control haemorrhage and prevent re-bleeding during the critical five days following the onset of bleeding. EVB is a life threatening condition and the mortality rate is high (about 15% a 25%) in the first six weeks following the haemorrhage. EVB is the cause of about 70% of gastro-intestinal bleeding in patients suffering from liver cirrhosis.
