Secretin
Sekvencia:H-His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Leu-Ser-Arg-Leu-Arg-Asp-Ser-Ala-Arg-Leu-Gln-Arg-Leu-Leu-Gln- Gly-Leu-Val-NH2
Alias : Secretin, Prasací sekretín, Bravčový sekretín, Secrepan, Secretin-Ferring, Secretolin,Ľudský sekretín
Cas č.: 17034-35-4
EINECS : 241-105-3
Molekulárny vzorec: C130H220N44O41
Molekulová hmotnosť: 3055.47
Čistota (HPLC): 98.0%min.
Vzhľad: Biely prášok
Jediná nečistota (HPLC): 1.0%max
Aminokyselinové zloženie: ±10 % teoretickej hodnoty
Obsah peptidov (N %): >80.0%
Obsah vody(Karl Fischer): <6.0%
Obsah acetátu (HPIC): <15.0%
PANI(ESI): Konzistentné
Hmotnostná bilancia: 95.0~105,0 %
stupňa : Farmaceutická trieda
Skladovanie: ZATVORENÉ, nižšie 2 ~ 8 ℃ konzervácia
Použitie : Sekretín acetát je hormón, ktorý je zodpovedný za kontrolu prostredia dvanástnika reguláciou sekrécie pankreasu a žalúdka a zároveň reguláciou vodnej homeostázy v tele zvieraťa.. Konkrétne, pomáha regulovať pH dvanástnika inhibíciou sekrécie žalúdočnej kyseliny z parietálnych buniek žalúdka a zvýšením stimulácie produkcie bikarbonátu v centroacinárnych bunkách z pankreasu.
Secretin is a hormone that regulates water homeostasis throughout the body and influences the environment of the duodenum by regulating secretions in the stomach, pankreasu, and liver. It is a peptide hormone produced in the S cells of the duodenum, which are located in the intestinal glands.In humans, the secretin peptide is encoded by the SCT gene.
Secretin helps regulate the pH of the duodenum by inhibiting the secretion of gastric acid from the parietal cells of the stomach and stimulating the production of bicarbonate from the ductal cells of the pancreas.It also stimulates the secretion of bicarbonate and water by cholangiocytes in the bile duct, protecting it from bile acids by controlling the pH and promoting the flow in the duct.Meanwhile, in concert with secretin's actions, the other main hormone simultaneously issued by the duodenum, cholecystokinin (CCK), is stimulating the gallbladder to contract, delivering its stored bile.
