secretina
Secuencia:H-His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Leu-Ser-Arg-Leu-Arg-Asp-Ser-Ala-Arg-Leu-Gln-Arg-Leu-Leu-Gln- Gly-Leu-Val-NH2
Alias : secretina, secretina de cerdo, secretina porcina, Secrepán, Secretin-Ferring, secretolina,Secretina humana
No CAS.: 17034-35-4
EINECS : 241-105-3
Fórmula molecular: C130H220N44O41
Peso molecular: 3055.47
Pureza (HPLC): 98.0%min.
Apariencia: polvo blanco
impureza única (HPLC): 1.0%máximo
Composición de aminoácidos: ±10% del teórico
Contenido de péptidos (NORTE%): >80.0%
Contenido de agua(karl fischer): <6.0%
Contenido de acetato (HPIC): <15.0%
EM(ESI): Coherente
Balance de masa: 95.0~105,0%
Calificación : Grado farmacéutico
Almacenamiento: Cerrado, abajo 2 ~ 8 ℃ preservación
Uso : El acetato de secretina es una hormona que es responsable de controlar el ambiente del duodeno al regular las secreciones pancreáticas y estomacales mientras regula la homeostasis del agua en todo el cuerpo de un animal.. Específicamente, ayuda a regular el pH del duodeno al inhibir la secreción de ácido gástrico de las células parietales del estómago y aumentar la estimulación de la producción de bicarbonato en las células centroacinares del páncreas.
Secretin is a hormone that regulates water homeostasis throughout the body and influences the environment of the duodenum by regulating secretions in the stomach, pancreas, and liver. It is a peptide hormone produced in the S cells of the duodenum, which are located in the intestinal glands.In humans, the secretin peptide is encoded by the SCT gene.
Secretin helps regulate the pH of the duodenum by inhibiting the secretion of gastric acid from the parietal cells of the stomach and stimulating the production of bicarbonate from the ductal cells of the pancreas.It also stimulates the secretion of bicarbonate and water by cholangiocytes in the bile duct, protecting it from bile acids by controlling the pH and promoting the flow in the duct.Meanwhile, in concert with secretin's actions, the other main hormone simultaneously issued by the duodenum, cholecystokinin (CCK), is stimulating the gallbladder to contract, delivering its stored bile.
