Sekretien
Volgorde:H-Sy-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Leu-Ser-Arg-Leu-Arg-Asp-Ser-Ala-Arg-Leu-Gln-Arg-Leu-Leu-Gln- Gly-Leu-Val-NH2
Alias : Sekretien, Vark sekretien, Varksekretien, Secrepan, Secretin-Ferring, Sekretolien,Menslike sekretien
Cas No.: 17034-35-4
EINECS : 241-105-3
Molekulêre Formule: C130H220N44O41
Molekulêre gewig: 3055.47
Reinheid (HPLC): 98.0%min.
Voorkoms: Wit poeier
Enkele Onreinheid (HPLC): 1.0%maks
Aminosuur samestelling: ±10% van teoreties
Peptied inhoud (N%): >80.0%
Waterinhoud(Karl Fischer): <6.0%
Asetaat inhoud (HPIC): <15.0%
MS(ESI): Konsekwent
Massabalans: 95.0~105,0%
Graad : Farmaseutiese Graad
Berging: Gesluit, hieronder 2 ~ 8℃ bewaring
Gebruik : Sekretienasetaat is 'n hormoon wat verantwoordelik is vir die beheer van die omgewing van 'n duodenum deur pankreas- en maagafskeidings te reguleer terwyl die waterhomeostase deur 'n dier se liggaam gereguleer word.. Spesifiek, dit help om die duodenum se pH te reguleer deur die afskeiding van maagsuur uit die pariëtale selle van die maag te inhibeer en die stimulering van die bikarbonaatproduksie in die sentroacinêre selle vanaf die pankreas te verhoog..
Secretin is a hormone that regulates water homeostasis throughout the body and influences the environment of the duodenum by regulating secretions in the stomach, pancreas, and liver. It is a peptide hormone produced in the S cells of the duodenum, which are located in the intestinal glands.In humans, the secretin peptide is encoded by the SCT gene.
Secretin helps regulate the pH of the duodenum by inhibiting the secretion of gastric acid from the parietal cells of the stomach and stimulating the production of bicarbonate from the ductal cells of the pancreas.It also stimulates the secretion of bicarbonate and water by cholangiocytes in the bile duct, protecting it from bile acids by controlling the pH and promoting the flow in the duct.Meanwhile, in concert with secretin's actions, the other main hormone simultaneously issued by the duodenum, cholecystokinin (CCK), is stimulating the gallbladder to contract, delivering its stored bile.
