productnaam:Ziconotide-acetaat,Prialt
CAS-registratienummer:: 107452-89-1
Moleculaire formule: C102H172N36O32S7
Molecuulgewicht: 2639.01
Reeks: Cys-Lys-Gly-Lys-Gly-Ala-Lys-Cys-Ser-Arg-Leu-Met-Tyr-Asp-Cys-Cys-Thr-Gly-Ser-Cys-Arg-Ser-Gly-Lys-Cys- NH2(Disfulde-brug: 1-16, 8-20, 15-25)
Uiterlijk: Wit poeder
Cijfer: Farmaceutische kwaliteit:
Water inhoud(Karl Fischer): 5.0%
Acetaat inhoud(door HPLC): 12.0%
Aminozuursamenstelling: 10% van theoretische
Zuiverheid(door HPLC): 98.0%
Enkele onzuiverheid(door HPLC): 1.0%
Peptide-inhoud(door %N ): 80%
Assay(door watervrij, Azijnzuurvrij ): 95.0~105,0%
Opslag: Koel(2~8 ) & droge plaats beschermd tegen licht, houd het pakket dicht wanneer het niet in gebruik is.
Ziconotide (also known as SNX-111) is a neurotoxic peptide derived from the cone snail Conus magus comprising 25 amino acids with three disulphide bonds. Other such peptides, collectively termed conotoxins, exist, and some have shown efficacy in binding specific subsets of calcium channels; ziconotide is used in part because it can be synthesized without loss of proper bond formation or structural elements.Ziconotide is used to manage severe chronic pain refractory to other methods, through its ability to inhibit N-type calcium channels involved in nociceptive signalling.
Ziconotide is an N-type calcium channel antagonist used to manage patients with severe chronic pain who cannot tolerate, or who have not responded adequately to other treatments such as intrathecal morphine and systemic analgesics.
Ziconotide inhibits N-type calcium channels involved in nociceptive signalling, primarily in the dorsal horn of the spinal cord.Although binding is reversible, careful dosing is required to ensure therapeutic effects while minimizing adverse effects, and ziconotide has been described as possessing a narrow therapeutic window.Patients taking ziconontide may experience cognitive and neuropsychiatric symptoms, reduced levels of consciousness, and elevated serum creatine kinase levels. In aanvulling, ziconotide may increase the risk of infection, including serious cases of meningitis. Patients who withdraw from opiates for ziconotide initiation are advised to taper off the dose.
