商品名:酢酸ジコノチド,プリアルト
CAS登録番号: 107452-89-1
分子式: C102H172N36O32S7
分子量: 2639.01
順序: Cys-Lys-Gly-Lys-Gly-Ala-Lys-Cys-Ser-Arg-Leu-Met-Tyr-Asp-Cys-Cys-Thr-Gly-Ser-Cys-Arg-Ser-Gly-Lys-Cys- NH2(ディスフルデ橋: 1-16, 8-20, 15-25)
外観: 白い粉
学年: 医薬品グレード
含水量(カール・フィッシャー): 5.0%
アセテート含有量(HPLCによる): 12.0%
アミノ酸組成: 10% 理論上の
純度(HPLCによる): 98.0%
単一の不純物(HPLCによる): 1.0%
ペプチド含有量(%N ): 80%
アッセイ(無水による, 無酢酸 ): 95.0~105.0%
保管所: 涼しい(2~8 ) & 光から保護された乾燥した場所, 使用しないときはパッケージを閉じて保管してください.
Ziconotide (also known as SNX-111) is a neurotoxic peptide derived from the cone snail Conus magus comprising 25 amino acids with three disulphide bonds. Other such peptides, collectively termed conotoxins, exist, and some have shown efficacy in binding specific subsets of calcium channels; ziconotide is used in part because it can be synthesized without loss of proper bond formation or structural elements.Ziconotide is used to manage severe chronic pain refractory to other methods, through its ability to inhibit N-type calcium channels involved in nociceptive signalling.
Ziconotide is an N-type calcium channel antagonist used to manage patients with severe chronic pain who cannot tolerate, or who have not responded adequately to other treatments such as intrathecal morphine and systemic analgesics.
Ziconotide inhibits N-type calcium channels involved in nociceptive signalling, primarily in the dorsal horn of the spinal cord.Although binding is reversible, careful dosing is required to ensure therapeutic effects while minimizing adverse effects, and ziconotide has been described as possessing a narrow therapeutic window.Patients taking ziconontide may experience cognitive and neuropsychiatric symptoms, reduced levels of consciousness, and elevated serum creatine kinase levels. In addition, ziconotide may increase the risk of infection, including serious cases of meningitis. Patients who withdraw from opiates for ziconotide initiation are advised to taper off the dose.
