názov: Dibucaine Hydrochloride
CAS č.: 61-12-1
Vzorec: C20H30ClN3O2
Molekulová hmotnosť: 379.98
Synonymá: 4-Quinolinecarboxamide,2-butoxy-N-[2-(diethylamino)ethyl]-, monohydrochloride (9CI);Cinchoninamide,2-butoxy-N-[2-(diethylamino)ethyl]-, monohydrochloride (8CI);2-Butoxy-N-(2-diethylaminoethyl)cinchoninamide hydrochloride;2-Butoxy-N-(2-diethylaminoethyl)cinchoninic acid amide hydrochloride;2-n-Butoxy-N-(2-diethylaminoethyl)cinchoninamide hydrochloride;Benzolin (local anesthetic);Cincaine;Cincaine chloride;Cinchocainehydrochloride;Cinchocainium chloride;Nupercainehydrochloride;Percain;Percaine;Percamin S;Sovcain;Sovcaine;
EINECS: 200-498-1
Hustota: 1.071g/cm3
Bod topenia: 99-101 °C(lit.)
Dibucaine hydrochloride is a local anesthetic of the amide type now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted. The drug blocks both the initiation and conduction of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions. This reversibly stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and subsequent conduction blockade.
In combination sodium dibucaine hydrochloride is administered to dogs to induce rapid, humane, painless euthanasia. The euthanasia solution is toxic to wildlife. Euthanized animals must be properly disposed of by deep burial, incineration or other method in compliance with state and local laws.
1. Dibucaine hydrochloride is a local anesthetic of the amide-type now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted.
2. The drug blocks both the initiation and conduction of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions. This reversibly stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and subsequent conduction blockade. In combination sodium, dibucaine hydrochloride is administered to dogs to induce rapid, humane, painless euthanasia. The euthanasia solution is toxic to wildlife. Euthanized animals must be properly disposed of by deep burial, incineration, or other methods in compliance with state and local laws.
| Položka |
Štandardné |
Výsledky testu |
| Strata sušením |
≤ 2,0 % |
0.19% |
| Ťažké kovy |
≤10 ppm |
<10ppm |
| Voda |
≤ 1,0 % |
0.10% |
| Sulphated ash |
≤ 0,5 %, determined on 1.0 g. |
0.01% |
| Príbuzné látky |
Unspecified impurities: for each impurity |
≤ 0,10 % |
<0.10% |
| Total Impurity |
≤ 0,5 % |
0.18% |
| Čistota |
≥99,0 % |
99.70% |
| Skúška |
99.0%~101.0% (anhydrous substance). |
99.80% |
| Microbiological Analysis |
| Total plate count |
≤ 1000 cfu/g |
Vyhovuje |
| Salmonella |
Absent |
Negatívne |
| Skladovanie |
Preserve in well-closed, light-resistant and airtight containers. |
Vyhovuje |
