[ 順序 ] Ac-D-2-Nal-D-4-Cl-Phe-D-3-Pal-Ser-N-Me-Tyr-D-Asn-Leu-Lys(IPR)-Pro-D-Ala-NH2
[ 同義語 ] PPI 149 アセテート; プレナシス;アバレリクス
[ CAS番号. ] 183552-38-7
[ 分子式 ] C74H99ClN14O16
[ 分子量 ] 1476.138
[ 密度 ] 1.287 g/cm3
[ 沸点 ] 1688.37 °Cで 760 mmHg
[ 引火点 ] 974.891 ℃
[ 外観 ] 白い粉
[ 応用 ] 医薬品有効成分
[ 純度 ] 98%
[ 主な機能 ]
科学研究のみ, 人体への直接使用不可
Abarelix is a synthetic decapeptide and antagonist of naturally occurring gonadotropin-releasing hormone (GnRH). Abarelix directly and competitively binds to and blocks the gonadotropin releasing hormone receptor in the anterior pituitary gland, thereby inhibiting the secretion and release of luteinizing hormone (左側) and follicle stimulating hormone (FSH). In males, the inhibition of LH secretion prevents the release of testosterone. As a result, this may relieve symptoms associated with prostate hypertrophy or prostate cancer, since testosterone is required to sustain prostate growth.
Abarelix Acetate is an injectable gonadotropin-releasing hormone antagonist (GnRH antagonist). Abarelix Acetate is primarily used in oncology to reduce the amount made in patients with advanced symptomatic prostate cancer for which no other treatment options are available.
