| Meno Produktu |
Triptorelin Acetate |
| CAS NO. |
140194-24-7 |
| MF |
C64H82N18O13 |
| MW |
1311.45 |
| EINECS č. |
N/A |
| Čistota |
99% |
| Vzhľad |
White freeze dried powder |
| Skladovanie |
Store at -20°C |
Triptorelin is a gonadotropin-releasing hormone agonist used as the acetate or pamoate salts. By causing constant stimulation of the pituitary, it decreases pituitary secretion of gonadotropins luteinizing hormone and follicle stimulating hormone. Rovnako ako iné agonisty GnRH, triptorelin may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, precocious puberty, stavy závislé od estrogénu, a v asistovanej reprodukcii. Triptorelin is marketed under the brand names Decapeptyl and Diphereline and Gonapeptyl.
Triptorelin,a decapeptide (pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2), je agonista hormónu uvoľňujúceho gonadotropín (GnRH agonista) used as the acetate or pamoate salts. By causing constant stimulation of the pituitary, it decreases pituitary secretion of gonadotropins luteinizing hormone (LH) and follicle stimulating hormone (FSH). Rovnako ako iné agonisty GnRH, triptorelin may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, precocious puberty, stavy závislé od estrogénu (ako je endometrióza alebo maternicové myómy), a v asistovanej reprodukcii. It is also used as therapy in cases of gender dysphoria.
Triptorelin is a GNRH agaonist shown to inhibit estradiol-induced cancer cell proliferationIn vivo.
1. Triptorelin can improve the pregnancy rate by 12% do 15% in ewes6 and downregulate ovarian GNRHR-I expression of female rats, especially in late-growing follicles.
2. Triptorelin immunity blocked EET and UWT, inhibited uterine growth and development and enhance the expression levels s of ESR1, LHR, and FSHR proteins.
3. Triptorelin may be used in the treatment of hormone-responsive cancers such as breast cancer or prostate cancer, precocious puberty, stavy závislé od estrogénu, and assisted reproduction.
Jediná nečistota (HPLC): 1.0%max
Aminokyselinové zloženie: ±10 % teoretickej hodnoty
Obsah peptidov (N %): ≥80,0 %
Obsah vody(Karl Fischer): ≤ 6,0 %
Triptorelin Acetate Acetate Content (HPIC): ≤ 15,0 %
Triptorelin Acetate MS(ESI): Konzistentné
Triptorelin Acetate Mass Balance: 95.0~105,0 %
Triptorelin Acetate Specific Rotation (20/D): -65.0～-75.0°(c=0.5 1%HAc)
