トリプトレリン酢酸塩 CAS:140194-24-7

Triptorelin is a gonadotropin-releasing hormone agonist used as the acetate or pamoate salts. By causing constant stimulation of the pituitary, it decreases pituitary secretion of gonadotropins luteinizing hormone and follicle stimulating hormone. 他のGnRHアゴニストと同様, triptorelin may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, precocious puberty, エストロゲン依存性疾患, そして生殖補助医療においては. Triptorelin is marketed under the brand names Decapeptyl and Diphereline and Gonapeptyl.

Triptorelin,a decapeptide (pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2), ゴナドトロピン放出ホルモン作動薬です (GnRHアゴニスト) used as the acetate or pamoate salts. By causing constant stimulation of the pituitary, it decreases pituitary secretion of gonadotropins luteinizing hormone (左側) and follicle stimulating hormone (FSH). 他のGnRHアゴニストと同様, triptorelin may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, precocious puberty, エストロゲン依存性疾患 (子宮内膜症や子宮筋腫など), そして生殖補助医療においては. It is also used as therapy in cases of gender dysphoria.

Triptorelin is a GNRH agaonist shown to inhibit estradiol-induced cancer cell proliferationIn vivo.

1. Triptorelin can improve the pregnancy rate by 12% に 15% in ewes6 and downregulate ovarian GNRHR-I expression of female rats, especially in late-growing follicles.

2. Triptorelin immunity blocked EET and UWT, inhibited uterine growth and development and enhance the expression levels s of ESR1, LHR, and FSHR proteins.

3. Triptorelin may be used in the treatment of hormone-responsive cancers such as breast cancer or prostate cancer, precocious puberty, エストロゲン依存性疾患, and assisted reproduction.

単一の不純物 (HPLC): 1.0%最大
アミノ酸組成: 理論値の±10%
ペプチド含有量 (N%): ≧80.0%
含水量(カール・フィッシャー): ≤6.0%
Triptorelin Acetate Acetate Content (HPIC): ≤15.0%
Triptorelin Acetate MS(ESI): 一貫性のある
Triptorelin Acetate Mass Balance: 95.0~105.0%
Triptorelin Acetate Specific Rotation (20/D): -65.0～-75.0°(c=0.5 1%HAc)