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Active Pharmaceuticals

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  • Specifications
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  • COA
Product Name Triamcinolon Acetonide
CAS NO: 76-25-5
Molecular Formular C24H31FO6
EINECS NO 200-948-7
Purity 99%
Appearance powder

Triamcinolone acetonide is a synthetic corticosteroid used to treat various skin conditions, relieve the discomfort of mouth soresand in nasal spray form as an over-the-counter relief for allergic and perennial allergic rhinitis.It is a more potent derivative of triamcinolone, being about 8 times as potent as prednisone.

Triamcinolone acetonide is an acetate derivative of triamcinolone A. It's a moderate glucocorticoid. The effect is similar to that of Triancillon, with anti-inflammatory, anti-pruritus and vasoconstriction effects, water and sodium retention effect is weak, among which the anti-inflammatory effect is stronger and lasting. The anti-inflammatory activity of 4mg triamcinolone was approximately equivalent to 5mg of prednisolone or 20mg of hydrocortisone. Triamcinolone acetonide is a long-acting adrenocorticosteroid, which has anti-inflammatory, anti-pruritus and vasoconstriction effects similar to that of Triancillone. Its anti-inflammatory and anti-allergic effect is strong and lasting, the effect is 20 to 30 times greater than cortisone. Triamcinolone acetonide has anti-inflammatory, anti-pruritus and vasoconstriction effects. Its anti - inflammatory and anti - allergic effects are strong and lasting. To dermatitis and other skin diseases, can be wiped by the skin, closed application wrapped therapy, and absorbed by the skin. Triamcinolone acetonide is extremely well tolerated for topical use.

ITEMS OF ANALYSIS SPECIFICATIONS RESULT
Appearance White or almost white crystalline powder almost white crystalline powder
Solubility Practically insoluble in water,sparingly soluble in ethanol Complies
Identification(IR,TLC) Complies with the standard Complies
Specific optical rotation +110°~+117° +115°
Water No more than 2.0% 0.28%
Residual Solvents Methanol≤3000ppm 188ppm
Dimethyformamide≤880ppm n.d
Acetone≤5000ppm 413ppm
Dichloromethane≤600ppm n.d
Particle size 90%≤30um Complies
Related substances
Impurity B No more than 0.2% 0.05%
Inpurity C No more than 0.15% 0.02%
Unspecified impurity No more than 0.1% 0.06%
Total impurities No more than 0.5% 0.26%
Assay 97%~103% 98.3%
Conclusion Comply with the requirements of EP 9.0.

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