Ацетат секретина - это гормон, который отвечает за контроль среды двенадцатиперстной кишки, регулируя секрецию поджелудочной железы и желудка, а также регулируя водный гомеостаз во всем теле животного.. Конкретно, помогает регулировать рН двенадцатиперстной кишки, ингибируя секрецию желудочного сока париетальными клетками желудка и усиливая выработку бикарбонатов в центроацинарных клетках поджелудочной железы.
The first species was found in animal hormone. As a basic polypeptide. Composed of 27 аминокислотные остатки, containing 11 kinds of amino acids. Bayless and Starling (Bayliss and Starling) is equal to the discovery in 1902. Generated secretin cells as the "С" cells, mainly in the duodenal mucosa, a small amount of the distribution in the jejunum, ileum and gastric antrum.
Secretin Acetate, also called secretin, has recently been in the brain and purified, therefore also joined the ranks of brain gut peptide. Role in stimulating the pancreas to secrete large amounts of bicarbonate rich pancreatic juice, to produce maximal stimulation of secretin dose on human, dog, свинья, as an intravenous injection or intravenous infusion per kg per hour 1 clinical units, the equivalent of 200 к 250 ng, strengthen weak effect on pancreatic enzyme secretion, but as with Pro pancreozymin given together, increased pancreozymin secretion, has inhibitory effect on human, dog, rat gastric acid secretion and gastrointestinal activity. Exogenous secretin, with a half-life of 4.1 minutes, metabolic clearance rate of 15 ml / мин / kg body weight.
