酢酸セクレチンは、動物の体全体の水分恒常性を調節しながら、膵臓と胃の分泌を調節することにより、十二指腸の環境を制御する役割を担うホルモンです。. 具体的には, 胃の壁細胞からの胃酸の分泌を阻害し、膵臓からの中心腺房細胞における重炭酸塩産生の刺激を増加させることにより、十二指腸のpHを調節するのに役立ちます.
The first species was found in animal hormone. As a basic polypeptide. Composed of 27 amino acid residues, containing 11 kinds of amino acids. Bayless and Starling (Bayliss and Starling) is equal to the discovery in 1902. Generated secretin cells as the "S" cells, mainly in the duodenal mucosa, a small amount of the distribution in the jejunum, ileum and gastric antrum.
Secretin Acetate, also called secretin, has recently been in the brain and purified, therefore also joined the ranks of brain gut peptide. Role in stimulating the pancreas to secrete large amounts of bicarbonate rich pancreatic juice, to produce maximal stimulation of secretin dose on human, dog, 豚, as an intravenous injection or intravenous infusion per kg per hour 1 clinical units, the equivalent of 200 に 250 ng, strengthen weak effect on pancreatic enzyme secretion, but as with Pro pancreozymin given together, increased pancreozymin secretion, has inhibitory effect on human, dog, rat gastric acid secretion and gastrointestinal activity. Exogenous secretin, with a half-life of 4.1 minutes, metabolic clearance rate of 15 ml / 分 / kg body weight.
