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Active Pharmaceuticals

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  • Specifications
  • Product Description
  • Product Usage
  • COA
Product Name Quinine Sulphate
Cas 804-63-7
MF C40H50N4O8S
Molecular weight 746.91
melting point 173~177ºC
EINECS 212-359-2
Odor Characteristic
Grade Medchine Grade
Specification 99%
Appearance White crystalline powder

Quinine sulphate s a substance that was first obtained by processing the bark of the cinchona tree, a South American native plant that has been used as a fever reducer by Native Americans for centuries. This substance has been used historically to treat malaria, along with some other medical conditions, and although a number of antimalarial drugs are on the market today, it is still used in some regions. It is also used commercially as an additive to tonic water, a soft drink that is used as a mixer for other drinks in addition to being consumed straight.

Quinine is a kind of alkaloid derived from the bark of the cinchona tree.It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633.Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose.Quinine was used commonly and as a bitter and flavoring agent, and is still useful for the treatment of babesiosis.Quinine is also useful in some muscular disorders, especially nocturnal leg cramps and myotonia congenita, because of its direct effects on muscle membrane and sodium channels. The mechanisms of its antimalarial effects are not well understood.

ITEMS Test Standard TEST RESULT
DESCRIPTION A white or almost white powder Complies
SOLUBILITY Very soluble in water; soluble in ethanol (96%) Complies
MELTING POINT 233-235 ºC 234ºC
SPECIFIC OPTICAL ROTATION -223-229° (C=2, 0.1M HCl) -241º
SULPHATED ASH ≤0.1% 0.05%
BARIUM This product is 0.2g, dissolved in 10ml water, add dilute sulfuric acid 1ml, 15 minutes, turbidity shall not occur Complies
THE RELATED IMPURITIES ≤ 1.5% 0.9%
LOSS ON DRYING 6.0%-10.0% 8.0%
RESIDUE ON IGNITION ≤ 0.15% 0.05%
PH pH=2.0-3.0 2.5
ASSAY 99.0%-101.0% 99.2%
TEST CONCLUSION The product complies with BP2009 and CP2005 standards

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