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Active Pharmaceuticals

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Name: L(-)-Epinephrine
English synonym: Renostyptin
CAS Number: 51-43-4
Molecular formula: C9H13NO3
Molecular mass: 183.2
EINECS number: 200-098-7

L-adrenaline, also known as L-Epinephrine, is extracted from the adrenal medulla of domestic animals (cattle and sheep) or synthesized by artificial methods, and has agonistic effects on both α and β receptors. Adrenaline is a hormone secreted by chromophores in the adrenal medulla. It is mainly involved in the regulation of sympathetic nervous system.

L-Epinephrine is white or off-white crystalline powder, odorless and bitter in taste. Very slightly soluble in water, insoluble in organic solvents such as ethanol and chloroform, soluble in mineral acid or sodium hydroxide solution. Unstable in neutral or alkaline aqueous solution, saturated aqueous Chemicalbook solution shows weak alkaline reaction. Its hydrochloride is commonly used, easily soluble in water, 0.1% aqueous solution pH 2.5~5.0, the product and its salt are easily decomposed and oxidized to pink to brownish red when encountering oxides, bases, light and heat.

L-adrenaline is used for allergic diseases: subcutaneous or intramuscular injection can treat allergic diseases, such as anaphylaxis, urticaria, bronchial asthma, hoof lobe inflammation, etc. It is also effective for allergic reactions caused by immune serum and vaccines.

L-adrenaline is applied in combination with local anesthetics: 0.5~1ml of 0.1% adrenaline solution is added to every 100ml of local anesthetics to constrict local blood vessels and delay the absorption of local anesthetics, which can prolong the anesthesia time and reduce the toxic reaction of anesthetics. 4. Topical use as local hemostatic drug: 1:5000~1:100,000 solution is used locally to make local blood vessels constrict and stop bleeding of nasal mucosa, uterus, gums or surgical site, etc.

Items Specification Results
Characters White or greyish-white crystalline odorless soluble greyish-white crystalline
powder,freely soluble in acid water,slightly odorless powder
in alcohol ,practically insoluble in ether.
Identificaion 0.10N iodine deep red color validity
Specific rotaion Between -50.0°and -53.5° -51.0°
Loss on drying Not more than 2.0% 0.5%
Residue on lgnition Negligible Negligible
Limit of adrenalone At 310 nm not more than 0.20 0.027
Limit of noreponephrine Not more than 4.0% 1.0%
Assay Not less than 97.0% and not more than 102.0% 99.5%
Residula solvents Methanol: not more than 3000ppm Methanol:1500ppm
Storage Store in vacuum and protected from light
CONCLUSION: The above product complies with the standard of contract. UPS32

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