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Active Pharmaceuticals

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Nomen Hydrochlorothiazide
Formulae hypotheticae C7H8ClN3O4S2
M. Pondus 297.74
CAS Subcriptio Number 58-93-5
EINECS Number 200-403-3
Liquescens punctum 273 °C
Ferveret 577.0±60.0 °C
Solubilitas H2O : 722mg/L(25 C)
Densitas 1.2545 g/cm3

Hydrochlorothiazide, also known as dihydrochlorothiazide, dihydrokeuridazide, thiazide diuretics, has a medium effect diuretic effect. The active reabsorption of Cl- and passive absorption of Na+ were inhibited by acting on the cortical part of the ascending ramus of the loop of medullary. Autem, this product also has antihypertensive effect and antidiuretic effect. It is suitable for all kinds of edema, especially for cardiogenic edema. It can also be used as antihypertensive drugs for the treatment of light and medium hypertension. It is also effective for diabetes insipidus and idiopathic hypercalcemia. Commonly used thiazide diuretics include hydrochlorothiazide, chlorothalidone,indapamide and so on.

It mainly inhibits the reabsorption of Na+ and Cl- at the proximal end of the distal convoluted tubule and increases the excretion of sodium chloride by the kidney, resulting in diuretic effect. It is a medium effect diuretic drug. This product has the effect of lowering blood pressure, which can be strengthened when used together with Li's medicinal paste, antihypertensive shen paste or Apocynum. This product also has antidiuretic effects and can be used to treat diabetes insipidus.

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