Product name:Gestonoronacetat / Gestonorone Acetate
CAS:31981-44-9
Synonyms:17-Hydroxy-19-norpregn-4-ene-3,20-dione 17-acetate；17alpha-Hydroxy-19-norprogesterone-17alpha acetate；19-Nor-17alpha-hydroxyprogesterone acetate,Norhydroxyprogesterone Acetate
Molecular Formula:C22H30O4
Molecular Weight:358.47
EINECS No.:250-882-8
Density:1.16g/cm3
Melting point:228-230℃
Gestonorone acetate, or gestronol acetate, also known as norhydroxyprogesterone acetate, is a progestin of the 19-norprogesterone and 17α-hydroxyprogesterone groups which was developed in the early 1960s but was never marketed.
Gestonorone acetate has been found to consistently inhibit ovulation at an oral dosage of 10 mg/day in combination with 50 μg/day oral ethinylestradiol.Weak or no endometrial effects were observed at an oral dosage of 100 mg/day, basal vacuoles appeared at 130 to 140 mg/day, and full endometrial secretory transformation occurred at 220 mg/day.
| TEST ITEMS |
SPECIFICATION |
RESULTS |
| Description |
White or Almost White Crystalline Powder |
white powder |
| Identification |
A.B. |
Positive |
| Assay |
97.0~103.0% |
99.1% |
| Loss On Drying |
1.0%max |
0.25% |
| Melting Point |
222~228°C |
227°C |
| Organic Volatile Impurities |
meets the requirement. |
Conforms |
| Related Substances |
meets the requirement. |
Conforms |
| Residual Solvents |
meets the requirement. |
Conforms |
| Particle Size |
100%20 microns |
Conforms |
| Conclusion |
The specification conform with USP30 standard |
