Synonymes: (DES-GLY10,PRO-NHET9)-LHRH;[DES-GLY10] LH-RH, ETHYL AMIDE
N ° CAS.: 38234-21-8
N° EINECS:636-807-5
Formule moléculaire: C55H76N16O12
Masse moléculaire: 1153.29 g/mole
Pureté: 99%min
Apparence: poudre blanche
Fertirelin is a synthetic luteinizing hormone-releasing hormone (LH-RH) analogue, and it is a potent LHRH agonist. After a transient increase, continuous administration results in downregulation of LH and FSH levels followed by a suppression of ovarian and testicular steroid biosynthesis.
Fertirelin was administered at the beginning of the protocol followed 7 days later by 500 μ G cloprosterol. Two days later, a second dose of fertirelin was given and AI performed 16-19 h later regardless of the incidence of behavioral oestrus. The conception rate did not differ between the 50 μ G fertirelin group (61.1%; N = 72) and the 100 μ G group.
Mainly has a strong angiotensin II vasoconstriction and increase in blood pressure. The mechanism is: 1. So that the body arteriole smooth muscle contraction, increased peripheral resistance; 2. So increase the release of adrenal aldosterone, causing sodium retention, increased blood volume; 3. Directly contribute to renal tubular sodium and water reabsorption; 4. So the brain central nervous sympathetic vasoconstrictor activity, causing increased peripheral vascular resistance; 5. Stimulate the adrenal medulla to release epinephrine and norepinephrine.
| Pureté (CLHP) |
99.0% |
| Apparence |
poudre blanche |
| Impureté unique(CLHP) |
1.0% |
| Composition en acides aminés |
10% de la théorie |
| Teneur en peptides(N %) |
80%(par %N) |
| Teneur en eau(Karl Fischer) |
6.0% |
| Teneur en acétate(PCSI) |
15.0% |
| MME(ESI) |
|
| Équilibre de la masse |
95.0～105,0 % |
