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Active Pharmaceuticals

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  • Specifications
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Product nomen Ethacridine Lactate Monohydrate / Rivanol
Cas numerus 6402-23-9
Formulae hypotheticae C15H15N3O.C3H6O3.H2O
M. pondus 361.4
Aspectus yellow powder
Liquescens punctum 243-245 °C(lit.)

Rivanol is the lactate-hydrate of α-ethoxy-6,9-diaminoacridine. It is a bactericidal preservative for external use and has a strong killing effect on gram-positive bacteria and a few gram-negative bacteria. , Has good antibacterial effect on cocci, especially streptococcus, and has strong activity in alkaline environment. This product is small in irritation, and the therapeutic concentration does not damage the general tissues, but it can stimulate the contraction of uterine smooth muscle, soften and relax the cervix. Therefore, it can be used to induce labor in women's mid-term pregnancy without obvious side effects.

1. Disinfection: Ethacridine Lactate Monohydrate is a disinfectant and antiseptic that inhibits the growth of Gram-positive bacteria, especially cocci. The solution can be used for the disinfection of small, lightly traumatised wounds and infected wounds. It can cause burning sensation, allergy, rash, itching and other adverse reactions.

2. Bactericidal: Ethacridine Lactate Monohydrate is disinfectant and bactericidal and can be used externally as a cream to disinfect small wounds on the skin surface. Occasionally there are allergic reactions.

3. Induction of labour in mid pregnancy: Ethacridine Lactate Monohydrate Injection is commonly used to induce labour in mid pregnancy by injecting a concentration into the amniotic cavity to cause sterile inflammation, stimulate uterine contractions and expel the foetus.

ITEM SPECIFICATION RESULTS
Descriptio Yellow crystalline powder; odourless

Soluble in hot water, soluble in boiling anhydrous ethanol, slightly soluble in water, slightly soluble in ethanol, insoluble in ether

Complies
Lepidium sativum Consistent with the

Pharmacopoeia (1,2,3,4)

Complies
PH 6.0-7.0 Complies
Chloride(Cl) The general principles of the pharmacopoeia 0801 Complies
Sulfate(SO4) The general principles of the

pharmacopoeia 0802

Complies
Related substance The general principles of the

pharmacopoeia 0512

Complies
Damnum in siccitate The general principles of the pharmacopoeia 0831

4.5%-5.5%

Complies
ignition residue The general principles of the pharmacopoeia 0841

≤0.1%

0.08%
Metalla gravis The general principles of the pharmacopoeia 0821

≤30ppm

Complies
Assay The general principles of the pharmacopoeia 0710 99.3%
conclusio Conform to Chinese Pharmacopoeia 2015

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