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Farmaceutické peptidy

» Peptidy » Farmaceutické peptidy

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Meno Produktu: Erytropoetín / EPO
Synonymá: ERYTHROPOIETÍN;Ľudský erytropoetín,EPO;ANTI-ERYTHROPOIETÍN(N-KONCOVKA) protilátka produkovaná u králika;ANTI-ERYTHROPOIETÍN(C-TERMINÁL) protilátka produkovaná u králika;INN=epoetín;ERYTHROPOIETÍN KRYS;EPO;erytropoetín z ľudského moču*pribl 100 Jednotky
CAS: 11096-26-7
MF: C22H22C1KN60
MW: 461.00098
EINECS: 234-317-2
Kategórie produktov: Peptidy;monoklonálna protilátka
Mol File: 11096-26-7.mol

Erytropoetín (EPO), also known as hematopoietin or hemopoietin, is a glycoprotein cytokine secreted by the kidney in response to cellular hypoxia; it stimulates red blood cell production (erythropoiesis) in the bone marrow. Low levels of EPO (around 10 mU/ml) are constantly secreted sufficient to compensate for normal red blood cell turnover. Common causes of cellular hypoxia resulting in elevated levels of EPO (up to 10,000 mU/ml) include any anemia, and hypoxemia due to chronic lung disease.

Erythropoietin is produced by interstitial fibroblasts in the kidney in close association with peritubular capillary and proximal convoluted tubule. It is also produced in perisinusoidal cells in the liver. Liver production predominates in the fetal and perinatal period; renal production predominates in adulthood.

Exogenous erythropoietin, recombinant human erythropoietin (rhEPO) is produced by recombinant DNA technology in cell culture and are collectively called erythropoiesis-stimulating agents (ESA): two examples are epoetin alfa and epoetin beta. ESAs are used in the treatment of anemia in chronic kidney disease, anemia in myelodysplasia, and in anemia from cancer chemotherapy. Risks of therapy include death, myocardial infarction, stroke, venous thromboembolism, and tumor recurrence. Risk increases when EPO treatment raises hemoglobin levels over 11-12 g/dl: this is to be avoided.

Erythropoietin is an essential hormone for red blood cell production. Without it, definitive erythropoiesis does not take place. Under hypoxic conditions, the kidney will produce and secrete erythropoietin to increase the production of red blood cells by targeting CFU-E, proerythroblast and basophilic erythroblast subsets in the differentiation. Erythropoietin has its primary effect on red blood cell progenitors and precursors (which are found in the bone marrow in humans) by promoting their survival through protecting these cells from apoptosis, or cell death.

Erythropoietin is the primary erythropoietic factor that cooperates with various other growth factors (e.g., IL-3, IL-6, glucocorticoids, and SCF) involved in the development of erythroid lineage from multipotent progenitors. The burst-forming unit-erythroid (BFU-E) cells start erythropoietin receptor expression and are sensitive to erythropoietin. Subsequent stage, the colony-forming unit-erythroid (CFU-E), expresses maximal erythropoietin receptor density and is completely dependent on erythropoietin for further differentiation. Precursors of red cells, the proerythroblasts and basophilic erythroblasts also express erythropoietin receptor and are therefore affected by it.

Product Spe. Product Spe.
HGH 2iu CJC1295 With DAC 2mg
HGH 10iu CJC1295 With DAC 5mg
HGH 15iu CJC1295 without DAC 2mg
HGH PEN 10iu CJC1295 without DAC 5mg
20iu Mod grf1-29 10mg
36iu PT141 (Bremelanotide) 10mg
HCG 5000iu Ipamorelin 2mg
HMG 75unit Ipamorelin 5mg
HGH Raw Powder >99% MGF 2mg
HCG Raw Powder >99% PEG MGF 2mg
Fragment HGH 176-191 2mg Sermorelin 2mg
Fragment HGH 176-191 5mg MT1 10mg
Fragment HGH 176-191 10mg MT2 10mg
500 TB 2mg Gonadorelin 2mg
500 TB 5mg DSIP 2mg
500 TB 10mg Triptoreli/Gnrh Triptoreli 2mg
GHRP-2 10mg selank 5mg
GHRP-2 5mg oxytocin 2mg
GHRP-2 2mg Tesamorelin 2mg
GHRP-6 10mg Aod9604 2mg
GHRP-6 5mg Epithalon 10mg
GHRP-6 2mg BPC157 10mg
IGF LR3-1 0.1mg BPC157 5mg
IGF LR3-1 0.5mg BPC157 2mg
IGF LR3-1 1mg Adipotode 2mg
Follistatin 344 1mg Aicar 50mg
GDF-8 1mg Semax 5mg
ACE-031 1mg Thymalin 63958-90-7 5mg
GHK-Cu 100mg Thymosin Alpha-1 5mg

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