Cyproheptadine hydrochloride, also known as dibenzocycloheptadine, antigentadine, is a hexahydropyridine antihistamine, which can compete with histamine released from tissues for H1 receptors on effector cells, thus preventing the onset of allergic reactions and relieving the spasmogenic and congestive effects of histamine, which has a strong H1 receptor antagonistic effect and stronger antihistamine effect than paracetamol and promethazine. It has mild to moderate anti-5-hydroxytryptamine effect and anticholinergic effect.
In addition, Cyproheptadine hydrochloride also has the effect of stimulating appetite, and weight gain can be seen after taking for a certain period of time.
Cyproheptadine hydrochloride is a white or yellowish crystalline powder, almost odorless, with a slightly bitter taste. It is soluble in methanol, dissolved in chloroform, slightly soluble in ethanol, slightly soluble in water and almost insoluble in ether.
Clinically, cyproheptadine hydrochloride is mainly used for acute and chronic urticaria (especially cold urticaria has good effect), papular urticaria, angioedema, allergic eczema, contact dermatitis, food allergic reaction, drug allergic reaction, allergic rhinitis, hay fever, allergic nodular inflammation, insect sting allergy and migraine.
Cyproheptadine hydrochloride has some therapeutic effect on bronchial asthma. It can also be used as an adjuvant treatment for Cushing's syndrome and acromegaly.
Cyproheptadine hydrochloride can also be used as an appetite enhancer for neurotic appetite fear.
Cyproheptadine hydrochloride has also been reported for the treatment of acanthosis nigricans and the prevention of necrotizing pyoderma.
