Bivalirudien
Volgorde:D-Phe-Pro-Arg-Pro-Gly-Gly-Gly-Gly-Asn-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr-Leu-OH
Alias:126:PN:WO2004076484BLADSY:31 beweerde proteïen;Angiomaks;BG 8967;Bivalirudien;Hirulog; Hirulog 1
Cas No.: 128270-60-0
Molekulêre Formule: C98H138N24O33
Molekulêre gewig: 2180.29
Reinheid (HPLC): 98.0%min.
Voorkoms: Wit poeier
Enkele Onreinheid (HPLC): 1.0%maks
Aminosuur samestelling: ±10% van teoreties
Peptied inhoud (N%): >80.0%
Waterinhoud (Karl Fischer): <8.0%
Trifluoracetaat inhoud(HPIC): >12.0%
MS (ESI): Konsekwent
Massabalans: 95.0~105,0%
Graad : Farmaseutiese Graad
Berging: Gesluit, hieronder 2 ~ 8℃ bewaring
Gebruik : Hierdie produk word hoofsaaklik gebruik vir die voorkoming van vaskulêre vorming intervensionele terapie in die behandeling van onstabiele angina, isgemiese komplikasies voor en na. Dit inhibeer beide sirkulerende en klontgebonde trombien, terwyl dit ook trombien-gemedieerde bloedplaatjieaktivering en aggregasie inhibeer.
Bivalirudien (Angiomax or Angiox, manufactured by The Medicines Company) is a specific and reversible direct thrombin inhibitor (DTI).
Bivalirudin is a DTI that overcomes many limitations seen with indirect thrombin inhibitors, such as heparin. Bivalirudin is a short, synthetic peptide that is potent, highly specific, and a reversible inhibitor of thrombin. It inhibits both circulating and clot-bound thrombin, terwyl dit ook trombien-gemedieerde bloedplaatjieaktivering en aggregasie inhibeer. Bivalirudin has a quick onset of action and a short half-life. It does not bind to plasma proteins (other than thrombin) or to red blood cells. Therefore it has a predictable antithrombotic response. There is no risk for Heparin Induced Thrombocytopenia/Heparin Induced Thrombosis-Thrombocytopenia Syndrome (HIT/HITTS). It does not require a binding cofactor such as antithrombin and does not activate platelets. These characteristics make bivalirudin an ideal alternative to heparin.
Bivalirudin clinical studies demonstrated consistent positive outcomes in patients with stable angina, unstable angina (UA), non-ST segment elevation myocardial infarction (NSTEMI), and ST-segment elevation myocardial infarction (STEMI) undergoing PCI in 7 major randomized trials
Bivalirudin is indicated for use as an anticoagulant in patients with unstable angina undergoing percutaneous transluminal coronary angioplasty (PTCA).
Bivalirudin with provisional use of glycoprotein IIb/IIIa inhibitor (GPI) is indicated for use as an anticoagulant in patients undergoing percutaneous coronary intervention (PCI).
Bivalirudin is indicated for patients with, or at risk of HIT/HITTS undergoing PCI.
Bivalirudin is intended for use with aspirin and has been studied only in patients receiving concomitant aspirin.
