Bivalirudin
Sekvens:D-Phe-Pro-Arg-Pro-Gly-Gly-Gly-Gly-Asn-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr-Leu-OH
Alias:126:PN:WO2004076484SIDE:31 påstått protein;Angiomaks;BG 8967;Bivalirudin;Hirulog; Hirulog 1
Cas No.: 128270-60-0
Molekylær formel: C98H138N24O33
Molekylær vekt: 2180.29
Renhet (HPLC): 98.0%min.
Utseende: Hvitt pulver
Enkel Urenhet (HPLC): 1.0%maks
Aminosyresammensetning: ±10 % av teoretisk
Peptidinnhold (N %): >80.0%
Vanninnhold (Karl Fischer): <8.0%
Trifluoracetat-innhold(HPIC): >12.0%
MS (ESI): Konsistent
Massebalanse: 95.0~105,0 %
Karakter : Farmasøytisk karakter
Oppbevaring: Lukket, under 2 ~ 8℃ bevaring
Bruk : Dette produktet brukes hovedsakelig til forebygging av vaskulærdannende intervensjonsterapi ved behandling av ustabil angina, iskemiske komplikasjoner før og etter. Det hemmer både sirkulerende og koagelbundet trombin, samtidig som den hemmer trombin-mediert blodplateaktivering og aggregering.
Bivalirudin (Angiomax or Angiox, manufactured by The Medicines Company) is a specific and reversible direct thrombin inhibitor (DTI).
Bivalirudin is a DTI that overcomes many limitations seen with indirect thrombin inhibitors, such as heparin. Bivalirudin is a short, synthetic peptide that is potent, highly specific, and a reversible inhibitor of thrombin. It inhibits both circulating and clot-bound thrombin, samtidig som den hemmer trombin-mediert blodplateaktivering og aggregering. Bivalirudin has a quick onset of action and a short half-life. It does not bind to plasma proteins (other than thrombin) or to red blood cells. Therefore it has a predictable antithrombotic response. There is no risk for Heparin Induced Thrombocytopenia/Heparin Induced Thrombosis-Thrombocytopenia Syndrome (HIT/HITTS). It does not require a binding cofactor such as antithrombin and does not activate platelets. These characteristics make bivalirudin an ideal alternative to heparin.
Bivalirudin clinical studies demonstrated consistent positive outcomes in patients with stable angina, unstable angina (UA), non-ST segment elevation myocardial infarction (NSTEMI), and ST-segment elevation myocardial infarction (STEMI) undergoing PCI in 7 major randomized trials
Bivalirudin is indicated for use as an anticoagulant in patients with unstable angina undergoing percutaneous transluminal coronary angioplasty (PTCA).
Bivalirudin with provisional use of glycoprotein IIb/IIIa inhibitor (GPI) is indicated for use as an anticoagulant in patients undergoing percutaneous coronary intervention (PCI).
Bivalirudin is indicated for patients with, or at risk of HIT/HITTS undergoing PCI.
Bivalirudin is intended for use with aspirin and has been studied only in patients receiving concomitant aspirin.
