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Pharmaceutical Peptides

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Product Name:Kisspeptin-10
CAS:374675-21-5 Assay:98%+
Molecular weight:1032.44g/mol Molecular formula: C63H83N17O14
Appearance: White powder Remarks: Only for research, not for human
Packing specifications (powder): 100mg, 1g, 10g Storage conditions: -20°C

Kisspeptin-10, also called Metastin (45-54), is a potent vasoconstrictor and endogenous ligand for the Kisspeptin receptor (KISS1, GPR54).The Effects of Kisspeptin-10 on Reproductive Hormone Release Show Sexual Dimorphism in Humans.Kisspeptin-10 Is a Potent Stimulator of LH and Increases Pulse Frequency in Men.

Metastin (45-54) is a 10 amino acid peptide that corresponds to the bioactive C-terminal 45-54 amino acids of metastin, a metastasis suppressor gene product. It acts as a potent agonist of GPR54 (OT7T175, AXOR12), with approximately 8-fold higher binding affinity than metastin (Ki values of 0.042 and 0.34 nM, respectively, for displacement of metastin (40-54)). Metastin (45-54) induces calcium mobilization in GPR54-transfected cells (EC50 = 0.18-1.1 nM). It inhibits the migration of GPR54-transfected CHO cells at concentrations of 10-100 nM, equaling the potency of full length metastin.

Kisspeptin-10 is an effective vasoconstrictor and angiogenesis inhibitor.Kisspeptin-10 inhibits tumor metastasis through its receptor GPR54.The kisspeptin-10-GPR54 system plays an important role in embryonic kidney development.Kisspeptin-10/GPR54 signaling induces osteoblast differentiation through NFATC4-mediated BMP2 expression.

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