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Active Pharmaceuticals

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  • COA
Product Name: Vinblastine sulfate
Synonyms: 29060le;exal;nsc49842;rozevinsulfate;velban;velbe;vincaleukoblastine,sulfate(1:1)(salt);Vinblastine, sulphate salt
CAS: 143-67-9
MF: C46H60N4O13S
MW: 909.05
EINECS: 205-606-0

Vinblastine is a medication used to treat a number of types of cancer including: Hodgkin's lymphoma, non-small cell lung cancer, bladder cancer, brain cancer, and testicular cancer among others.It is used intravenously and works by inhibiting mitosis.

1. It has vasodilating, blood thinning, and memory-enhancing actions.

2. It acts as a cerebral stimulant and vasodilator.

3. It is used to treat arteriosclerosis.

4. It is very effective in curing dementia caused due to insufficient blood supply to the brain.

5. It interferes with cells' ability to synthesize DNA and RNA.

Mainly used for the treatment of solid tumor. For malignant lymphoma, testicular neoplasm and choriocarcinoma curative effect is better. For lung, breast, ovarian, skin cancer, renal mother cell tumor and monocytes leukaemia also have certain curative effect.

Items Standards Results
Appearance White or off-white solid powder Complies
Identification By IR Complies
By HPLC Complies
Solubility Soluble in DMF, sparingly soluble in THF, slightly soluble in methanol and acetonitrile, very sightly soluble in ethanol and dichloromethane, insoluble in water Complies
Polymorphic Form Polymorphic form 1 Complies
Melting Point 211ºC~216ºC 212.8ºC~214.9ºC
Water Content ≤ 0.50% 0.10%
Heavy Metals ≤ 20ppm Complies
Residue on Ignition ≤ 0.20% 0.09%
Related Substance Any single impurity: ≤0.10% 0.06%
Total Impurities: ≤1.00% 0.16%
Assay                  (on the anhydrous basis) 98.0%~102.0% 99.94%
Particle Size D90: ≤100µm Complies
Reference Standard In-house Standard
Conclusion The product complied to In-house standard.

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