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Active Pharmaceuticals

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  • Specifications
  • Product Description
  • Product Usage
  • COA
Product Name Tolnaftate
CAS 2398-96-1
MF C19H17NOS
MW 307.41
Grade Medicine Grade
Appearance White or Yellowish Powder
Melting Point 110.5-111.5 dec.

Tolnaftate is a synthetic thiocarbamate used as an anti-fungal agent that may be sold without medical prescription in most jurisdictions. It is supplied as a cream, powder, spray, and liquid aerosol. Tolnaftate is used to treat fungal conditions such as jock itch, athlete's foot and ringworm.

Although the exact mechanism of action is not entirely known, it is believed to inhibit squalene epoxidase,an important enzyme in the biosynthetic pathway of ergosterol (a key component of the fungal membrane) in a similar way to allylamines.

Tolnaftate has been found to be generally slightly less effective than azoles when used to treat tinea pedis (athlete's foot). It is, however, useful when dealing with ringworm, especially when passed from pets to humans.

Tolnaftate has been found to be generally slightly less effective than azoles when used to treat tinea pedis (athlete's foot). Tolnaftate is, however, useful when dealing with ringworm, especially when passed from pets to humans.

Tolnaftate topical is used to treat skin infections such as athlete's foot, jock itch, and ringworm infections. Tolnaftate is also used, along with other antifungals, to treat infections of the nails, scalp, palms, and soles of the feet.

Items Specifications Result
Description A white crystalline powder ,odorless Complies
Identification (infrared absorption ) Positive Positive
Assay(on the dried basis): 99.4% 98.5%~101.5%
Residue on ignition 0.06% NMT 0.3%
Chloride <0.010% NMT0.05%
Sulfate <0.010% NMT0.03%
Iron <10ppm NMT30ppm
Heavy metals <8ppm NMT15ppm
Related compounds <0.5% NMT0.5%
Loss on drying 0.08% NMT0.3%
Total plate count 50/g NMT1000/g
Mold <10/g NMT100/g
Yeast <10/g NMT 100/g
E.Coli Not found Negative /10g
Salmonella Not found Negative /25g
Staphylococcus aureus Negative /10g Negative /10g
Conclusion Comply with USP36

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