nombre del producto: Tianeptine Ethyl Ester Sulfate
Chemical name: 7-[(3-CHLORO-6-METHYL-5,5-DIOXIDO-6,11-DIHYDRODIBENZO[C,F][1,2]THIAZEPIN-11-YL)AMINO]HEPTANOIC ACID ETHYL ESTER SULFATE SALT
No CAS.: 66981-77-9
Ensayo: >98.5%
Fórmula: C23H29ClN2O4SH2SO4
Tianeptine Ethyl Ester Sulfate is an improved salt of Tianeptine. It is not hygroscopic so handling the powder is a lot easier. Since it is not as readily absorbed and excreted from the body, the sulfate salt allows for a more controlled release of the Tianeptine over longer periods. Rather than having to dose three times with rapid peak effects and rapidly falling effects, the sulfate salt allows for one dose to maintain plasma levels in the body much longer than the sodium salt. These improved characteristics make Tianeptine Sulfate a novel addition.
Tianeptine Ethyl Ester sulfate cas 66981-77-9 is a salt of Tianeptin. Tianeptin, a tricyclic compound, is a selective facilitator of 5-HT (serotonin; sc-201146) uptake in vitro and in vivo. Additionally, tianeptin sodium Tianeptine is reported to act as a selective inhibitor of dopamine uptake . Tianeptin does not have a noted effect on monoamine tianeptine sodiumuptake. In a study utilizing purified synaptosomes from rat brain, Tianeptin was reported to enhance serotonin uptake in selective brain regions. Purified synaptosomes were obtained from rats and incubated with tritium-labeled 5-HT and Tianeptin66981-77-9 in vitro . The synaptosomes were then analyzed for uptake and release of 5-HT via a liquid scintillation.
1.Tianeptine sodium salt hydrate has been used as a selective serotonin reuptake enhancer (SSRE) positive control during serotonin transporter (SERT) assay in human embryonic kidney 293 cell lines.
2.Tricyclic compound with psychostimulant, anti-ulcer and anti-emetic properties.
3.Tianeptine (POSADA) (Stablon,Coaxil, Tatinol) is a selective serotonin reuptake enhancer (SSRE) drug used for treating major depressive episodes (mild,moderate, or severe).
| TEST ITEM |
SPECIFICATION |
RESULT |
| Apariencia |
White or almost white micro-crystalline powder |
polvo blanco |
| Solubilidad |
Insoluble in the water and methanol |
Cumple |
| Identificación |
By IR, to match with the standard. |
Cumple |
| |
The retention time of major peak of the sample solution corresponds to the standard |
Cumple |
| Related substance |
Individual impurity: Not more than 0.1% |
0.04% |
| |
Total impurities: Not more than 0.5% |
0.08% |
| Residue on ignation |
Not more than 0.2% |
0.01% |
| Pérdida por secado |
Not more than 1.0% |
0.18% |
| Metal pesado |
Not more than 20ppm |
< 20ppm |
| Ensayo (on anhydrous basis) |
98%-101% |
99.75% |
