Somatostatin CAS:51110-01-1

Somatostatina (also known as growth hormone-inhibiting hormone (GHIH) or somatotropin release-inhibiting factor (SRIF)) or somatotropin release-inhibiting hormone is a peptide hormone that regulates the endocrine system and affects neurotransmission and cell proliferation via interaction with G protein-coupled somatostatin receptors and inhibition of the release of numerous secondary hormones. Somatostatin regulates insulin and glucagon.

Somatostatin has two active forms produced by alternative cleavage of a single preproprotein: one of 14 aminoacidi, the other of 28 aminoacidi.

In all vertebrates, there exist six different somatostatin genes that have been named SS1, SS2, SS3, SS4, SS5, and SS6. The six different genes along with the five different somatostatin receptors allows somatostatin to possess a large range of functions. Humans have only one somatostatin gene, SST.

It can inhibit , thyroid stimulating hormone, the secretion of insulin, glucagon's. can inhibit secretion by the test meal and five pentagastrin stimulated gastric acid, pepsin and inhibit the release of gastrin. splanchnic blood flow can be significantly reduced, reducing portal pressure, reduced blood flow and pressure of collateral circulation, reduced hepatic blood flow. reduce gallbladder and pancreatic secretion of gastric secretion and outside of the small intestine, reducing the activity of pancreatic cells have a protective effect. inhibition of glucagon secretion. can affect the gastrointestinal absorption and nutritional function.

Singola impurità (HPLC) 1.0%max
Amino Acid Composition ± 10% di teorico
Contenuto peptidico (N%) ≥ 80.0%
Contenuto di acqua (Karl Fischer) ≤ 8.0%
Contenuto in acetato (HPC)≤ 15.0%
SM (ESI)Coerente
Rotazione specifica (20/D) -37.0~-47.0° (c=1 1%HAc)
Bilancio di massa 95,0~105,0%