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Local Anesthetic Drugs

» Pharmaceuticals » Local Anesthetic Drugs

  • Specifications
  • Product Description
  • Product Usage
  • COA
Product Name Procaine
CAS 59-46-1
Purity 99%
MF C13H20N2O2
MW 236.31
Appearance White powder
Storage Shading,confined preservation
Origion of Place China

Procaine is a local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block.

Procaine is a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodium channels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses. In addition, this agent increases electrical excitation threshold, reduces rate of rise of action potential and slows nerve impulse propagation thereby causing loss of sensation.

Procaine is a kind of local anesthetics. With low toxicity but quick and safe effects, procaine is suitable for local anesthesia, applied to the eye, ear, nose, teeth and other department operation, used for infiltration anesthesia, anesthesia and closed therapy supervisor. Procaine is also used in the production of procaine penicillin.

Test Items Specification Test Results
Appearance White crystals or a white crystalline powder Conform
Identification ABE. It appears positive reaction
Melting point 154degree~158degree 154degree~157degree
Acidity PH 5.0~6.5 PH=5.9
Appearance of solution Clear and colourless Conform
Loss on drying ≤0.5% 0.07%
Heavy metals ≤0.0005% Conform
Related substances ≤0.05% Conform
Sulphated ash ≤0.1% 0.05%
Assay ( on dry basis ) 99.0-101.0% 99.87%
Conclusion Conform to BP2005

 

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