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Steroids Excipient Portitorem

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CAS No.9005-65-6
Nomen chemicum:Tween 80
Synonyma: svo9;to10;mo55f;Tween;crill10;crill11;monitan;sorlate;tween81;crillet4
CBNumber:CB7741359
Formulae hypotheticae:C24H44O6
Formula Pondus:428.600006103516
Ferveret:>100°C
Densitas 1.08 g/mL at 20 °C
vapor pressure <1 mm Hg ( 20 °C)
refractive index n20/D 1.473
FEMA 2917 | POLYSORBATE 80
Mico punctum:>230 °F
storage temp. Store at RT.
form viscous liquid
color Amber
PH5-7 (50g/l, H2O, 20)
Aqua Solubility 5-10 g/100 mL at 23 C

Tween 80 is a synthetic non-ionic emulsifier widely used in cosmetics, food fields and pharmaceutical preparations.
Tween 60 (HLB value 14.9) and Tween 80 (HLB value 15.0) are commonly used in protein drinks. Due to its high HLB value and its price is much lower than emulsifiers such as sucrose esters with equal HLB values, it is usually used in combination with low HLB value monoglycerides, spanners, sucrose esters, etc. to meet the needs of various protein drinks.

As O/W type food emulsifier, used alone or mixed with Span-60, Span-65 and Span-80. my country stipulates that it can be used to emulsify natural pigments, and the maximum usage is 1.g/kg; the maximum usage in milk is 1.5g/kg; the maximum usage in ice cream and ice cream is 1.0g/kg.

This product has excellent emulsifying, dispersing, wetting and other properties. In the food industry, it is used as an emulsifier, dispersant and turbidity for soft drinks such as ice cream, bread, cakes, candies, etc. The dosage is 0.1% to 0.5% to prevent creamy food from splashing, food aging, and to improve quality, increase gloss, improve taste, and improve softness. Especially for creamy chocolate toffee, there is a clear anti-blooming effect. It can be used alone or together with food emulsifiers such as glycerides and sucrose esters to exert a synergistic effect. It is also widely used as a solubilizer in advanced cosmetics, light textiles, and pharmaceutical industries. It is also widely used in textiles, paints, emulsion explosives, pesticides, printing, petroleum and other industries as emulsifiers, stabilizers, lubricants, softeners, and antistatic agents.

Food use:

Polysorbates 80 is used as an emulsifier in foods.

For example, in ice cream, polysorbate is added up to 0.5% (v/v) concentration to make the ice cream smoother and easier to handle, as well as increasing its resistance to melting.Adding this substance prevents milk proteins from completely coating the fat droplets. This allows them to join together in chains and nets, which hold air in the mixture, and provide a firmer texture that holds its shape as the ice cream melts.

Health and beauty use:

Polysorbates 80 is also used as a surfactant in soaps and cosmetics (including eyedrops), or a solubilizer such as in a mouthwash. The cosmetic grade of polysorbate 80 may have more impurities than the food grade.

Medical use:

Polysorbates 80 is an excipient that is used to stabilize aqueous formulations of medications for parenteral administration, and used as an emulsifier in the manufacture of the popular antiarrhythmic amiodarone.It is also used as an excipient in some European and Canadian influenza vaccines.Influenza vaccines contain 25 μg of polysorbate 80 per dose.It is also used in the culture of Mycobacterium tuberculosis in Middlebrook 7H9 broth. It is also used as an emulsifier in the estrogen-regulating drug Estrasorb.

Items of analysis Specification Results
Aspectus Slight yellow to brown oil conforms
(mg//KOH/g)

 

≤2.0

 

0.3

 

(mg//KOH/g)

 

45~55

 

47.9

 

(mg//KOH/g)

 

65~80

 

75.8

 

(w/%)

 

≤0.25

 

0.2

 

(w%)

 

≤3.0

 

2.3

 

Pb(mg/kg)

 

≤2.0

 

<2

 

(mg/kg)

 

≤3.0

 

<3

 

oxyethylene group (w%)

 

65.0~69.5

 

8.4

 

conclusio Qualified

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