Nom du produit: NSI-189
Synonymes: NSI-189;(4-BENZYLPIPERAZIN-1-YL)-[2-(3-METHYLBUTYLAMINO)PYRIDIN-3-YL]METHANONE;(4-BENZYLPIPERAZIN-1-YL)(2-(ISOPENTYLAMINO)PYRIDIN-3-YL)METHANONE;[2-[(3-Methylbutyl)aminé]-3-pyridinyle][4-(phenylmethyl)-1-piperazinyl]méthanone;[2-[(3-Methylbutyl)aminé]-3-pyridinyle][4-(phenylmethyl)-1-piperazinyl]methanone NSI189;NSI-189 [2-[(3-Methylbutyl)aminé]-3-pyridinyle][4-(phenylmethyl)-1-piperazinyl]méthanone;NSI-189, >=98%;(4-benzylpiperazin-1-yl)-[2-(3-methylbutylamino)pyridin-3-yl]
CAS: 1270138-40-3
MF: C22H30N4O
MW: 366.4998
Point d'ébullition: 534.7±50.0 °C
Densité: 1.134±0,06g/cm3
NSI-189 is a benzylphiperizine-aminiopyridine, nootropic and neurogenic research chemical created by Neuralstem, Inc. that was derived from pyrazine and nicotinamide. Studies have shown that it stimulates neurogenesis of human hippocampus-derived neural stem cells in vivo and vitro . In healthy adult mice, NSI-189 has been shown to increase the hippocampal volume by 20% and reverse behavioral symptoms in mouse depression models, meaning at the source it could address depression . The hippocampus is responsible for spatial navigation, along with the consolidation of information from short-term memory to long-term memory.
The chemical entity stimulates new neuron growth in the hippocampus, which is an area of the brain that is believed to be contributory in conditions such as post-traumatic stress disorder (PTSD), Alzheimer's disease, and major depressive disorder (MDD).
1) Enhance cognition and memory formation.
2) Anxiolytic properties.
3) Anti-depressive effect .
4) Treatment of Alzheimer's and Parkinson's disease.
5) Increase coordination.
6) Improves mood.
7) Help fight fatigue.
8) Prevent oxidation within the brain.
9) Treat alcohol related brain damage.
| Éléments d'analyse |
spécification |
Résultats |
| Apparence |
Off-white powder |
Confrom |
| Identification |
IR and HPLC spectrum shall conform to the standard sample |
conform |
| Point de fusion |
83ºC~86ºC |
84.3ºC~85.6ºC |
| Perte au séchage |
Moins que 0.5% |
0.29% |
| Pureté(On Dried Base,CLHP) |
NLT 99.5 % |
99.62% |
| Impureté totale |
Moins que 0.5% |
0.33% |
| Résidus à l'allumage |
≤0.2% |
0.16% |
| Heavy métal |
≤20ppm |
conform |
| Conclusion |
Qualified |
