Product Name: NSI-189
Synonyms: NSI-189;(4-BENZYLPIPERAZIN-1-YL)-[2-(3-METHYLBUTYLAMINO)PYRIDIN-3-YL]METHANONE;(4-BENZYLPIPERAZIN-1-YL)(2-(ISOPENTYLAMINO)PYRIDIN-3-YL)METHANONE;[2-[(3-Methylbutyl)amino]-3-pyridinyl][4-(phenylmethyl)-1-piperazinyl]methanone;[2-[(3-Methylbutyl)amino]-3-pyridinyl][4-(phenylmethyl)-1-piperazinyl]methanone NSI189;NSI-189 [2-[(3-Methylbutyl)amino]-3-pyridinyl][4-(phenylmethyl)-1-piperazinyl]methanone;NSI-189, >=98%;(4-benzylpiperazin-1-yl)-[2-(3-methylbutylamino)pyridin-3-yl]
CAS: 1270138-40-3
MF: C22H30N4O
MW: 366.4998
Boiling point: 534.7±50.0 °C
Density: 1.134±0.06 g/cm3
NSI-189 is a benzylphiperizine-aminiopyridine, nootropic and neurogenic research chemical created by Neuralstem, Inc. that was derived from pyrazine and nicotinamide. Studies have shown that it stimulates neurogenesis of human hippocampus-derived neural stem cells in vivo and vitro . In healthy adult mice, NSI-189 has been shown to increase the hippocampal volume by 20% and reverse behavioral symptoms in mouse depression models, meaning at the source it could address depression . The hippocampus is responsible for spatial navigation, along with the consolidation of information from short-term memory to long-term memory.
The chemical entity stimulates new neuron growth in the hippocampus, which is an area of the brain that is believed to be contributory in conditions such as post-traumatic stress disorder (PTSD), Alzheimer's disease, and major depressive disorder (MDD).
1) Enhance cognition and memory formation.
2) Anxiolytic properties.
3) Anti-depressive effect .
4) Treatment of Alzheimer's and Parkinson's disease.
5) Increase coordination.
6) Improves mood.
7) Help fight fatigue.
8) Prevent oxidation within the brain.
9) Treat alcohol related brain damage.
Items of analysis |
Specification |
Results |
Appearance |
Off-white powder |
Confrom |
Identification |
IR and HPLC spectrum shall conform to the standard sample |
conform |
Melting Point |
83ºC~86ºC |
84.3ºC~85.6ºC |
Loss on Drying |
Less than 0.5% |
0.29% |
Purity(On Dried Base,HPLC) |
NLT 99.5 % |
99.62% |
Total Impurity |
Less than 0.5% |
0.33% |
Residue On Ignition |
≤0.2% |
0.16% |
Heavy metal |
≤20ppm |
conform |
Conclusion |
Qualified |