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Active Pharmaceuticals

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  • Specifications
  • Product Description
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  • COA
Product name Metformin
CAS number 657-24-9
Molecular Formula C4H11N5
Molecular Weight 129.16
Grade medical-grade
Appearance White fine powder
Assay 99%

Metformin, N,N-dimethylimidodicarbonimidicdiamide hydrochloride (Glucophage), is a bisguanidine.This class of agents is capable of reducing sugar absorptionfrom the gastrointestinal tract. Also, they can decrease gluconeogenesiswhile increasing glucose uptake by muscles andfat cells. These effects, in turn, lead to lower blood glucoselevels. Unlike the sulfonylureas, these are not hypoglycemicagents but rather can act as antihyperglycemics.  Often,metformin is coadministered with the nonsulfonylureas to improvethe efficacy of those agents.

1.Increase the sensibility of surrounding tissues to insulin and the insulin-mediated usage of amylaceum.
2.Increase the the amylaceum usage to those organization, such as brain, blood corpuscle, medulla renis, intestinal tract, skin and so on.
3.Restrain the heteroplasia of hepatic glycogen, lower the output of hepatic glycogen.
4.Restrain the intestinal wall cells from absorbing amylaceum.
5.Restrain the biosynthesis and storage of cholesterol, lower triglyceride, and total level of cholesterol.

Description White crystals or crystalline powder White crystals or crystalline powder
Identification Infrared absorption spectrum Infrared absorption spectrum
Specific rotation +26.3 °- +27.7° +26.9 °- +27.9°
[a]D20°
State of solution --- ≥ 98.0%
/Transmittance
Chloride (Cl) ≤ 0.05% ≤ 0.020%
Ammonium (NH4) --- ≤ 0.02%
Sulfate (SO4) ≤ 0.03% ≤ 0.020%
Iron (Fe) ≤ 0.003% ≤ 10PPm
Heavy metals (Pb) ≤ 0.0015% ≤ 10PPm
(As2O3) --- ≤ 1PPm
Other amino acids --- Chromatographically not detectable
Loss on drying ≤ 0.5% ≤ 0.5%
Residue on ignition ≤ 0.3% ≤ 0.10%
(sulfated)
Assay 98.5-101.5% 99.0 - 101.0%
PH --- 10.5-12.0
Organic volatile impurities Meets the requirements ---

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