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Steroidi femminili

» Steroidi crudi » Steroidi femminili

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Nome del prodotto: Megestrol
CAS RN 3562-63-8
EINECS 222-628-6
Molecular formula C24H32O4
Peso molecolare 384.5085
Utilizzo: Used for treating dysmenorrhea, sanguinamento uterino funzionale, endometriosis and endometrial adenocarcinoma

Megestrol, un 17 ligin-hydroxyprogesterone derivative, is a highly effective synthetic progesterone that has about 75 times the progesterone effect when taken orally and 50 times the progesterone effect when injected.

This product has obvious anti-estrogen effect, no estrogen or androgens activity, no protein assimilation effect. It can inhibit the release of hypothalamic releasing hormone (GnRH) and be used in adenohypophysis to reduce its sensitivity to GnRH, thereby blocking the release of pituitary and producing significant ovulation inhibition. Therefore, it is used together with ethinylestradiol as a short-acting contraceptive.

Megestrol acetate is used mainly as an appetite stimulant in a variety of conditions and as an antineoplastic agent in the treatment of breast, endometrial, and prostate cancers. When given in relatively high doses, it can substantially increase appetite in most individuals, even those with advanced cancer, and is often used to boost appetite and induce weight gain in patients with cancer or HIV/AIDS-associated cachexia. It is also used as a contraceptive in combination with an estrogen at relatively low doses.

In addition to its use in humans, megestrol acetate has been used extensively in veterinary medicine in the treatment of medical conditions in cats and dogs.

Articoli di prova Specifica Risultati del test
Aspetto esteriore White to creamy white crystalline powder Polvere cristallina bianca
Identificazione E Conforme
Completeness of solution Meets the requirements.500mg being Conforme
dissolved in 10ml of acetone Conforme
Solubilità Insolubile in acqua, sparingly soluble in Conforme
alcohol. Slightly soluble in ether and in Conforme
fixed oils, soluble in acetone; very soluble Conforme
nel cloroformio.
Intervallo di fusione 213ºC~220ºC 217C
Rotazione ottica specifica +8.8°~ +12.0° +11.6¡°
Acqua ≤0,5% 0.1%
Residue roration ≤0.2% 0.06
Metalli pesanti ≤0.002% Conforme
Saggio 97.0%~103,0% 99.6%
Residual solvents Methanol≤1000ppm 74ppm
Ethanol≤1000ppm 39ppm
Methylene chloride≤500ppm 28ppm
Tetrahydrofuran≤300ppm ND
Benzene≤2ppm ND

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