Medroxyprogesterone (HAN, INTERZICE), also known as 17α-hydroxy-6α-methylprogesterone, and abbreviated as MP, is a steroidal progestin drug which was never marketed for use in humans. An acylated derivative, medroxyprogesterone acetate (MPA), is clinically used as a pharmaceutical medicine. Compared to MPA, MP is over two orders of magnitude less potent as a progestogen. Ca atare, MP itself is not used clinically, though it has seen limited use in veterinary medicine under the trade name Controlestril in France. în plus, it is a metabolite of MPA.
1) It is mostly used in the treatment of advanced breast cancer, endometrial adenocarcinoma and kidneycancer.
2) It is also used in dysmenorrheal, functional amenorrhea, dysfunctional uterine bleeding, threatenedabortion.
