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アクティブ医薬品

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商品名 Alpha Lipoic Acid ほかの名前 Alpha Lipoic Acid
CAS番号. 62-46-4 M. F. C8H14O2S2
純度 99%分 M.W. 206.33
外観 Slightly yellow crystal powder 学年 USP

Lipoic acid is a coenzyme found in mitochondria that acts like a vitamin and neutralises free radicals that accelerate ageing and cause disease. Lipoic acid in the body through intestinal absorption into the cell, both fat soluble and water soluble characteristics, so it can pass through the whole body unimpeded, to reach any cell site, to provide comprehensive human performance, is a fat soluble and water soluble universal antioxidant. Lipoic acid acts as a coenzyme in two key oxidative decarboxylation reactions, Molecular structure diagram Molecular structure diagram In pyruvate dehydrogenase complex and α-ketoglutarate dehydrogenase complex, catalyze the production and transfer of acyl group. The lipoic acid can accept the acyl group to the acetyl group of pyruvate, form A thioester bond, and then transfer the acetyl group to the sulfur atom of the coenzyme A molecule. Dihydrothiooctam forming the auxiliary group can then be oxidized by dihydrothiooctam dehydrogenase (NAD required) to regenerate the oxidized thiooctam. α -lipoic acid contains disulfide five-member ring structure, high electron density, significant electrophilic and free radical reaction ability, so it has antioxidant, has high health care function and medical value (such as anti-fatty liver and reduce plasma cholesterol). In addition, the sulfhydryl group of lipoic acid is easy to REDOX reaction, so it can protect the sulfhydrase from heavy metal ions. Lipoic acid is widely distributed in nature, especially in liver and yeast cells. Lipoic acid is often present in foods together with vitamin B1. The human body can synthesize.

1. In the medical field: stabilize blood sugar, strengthen liver function, recover fatigue and improve dementia. Protect the body

2. In the field of beauty and cosmetics: Lipoic acid have amazing antioxidant ability, can remove skin aging caused by reactive oxygen species composition, and due to the smaller molecules than vitamin E, plus it is with water-soluble and fat-soluble, so skin is quite easy, especially for black rim of the eye, wrinkles and spots, such as effectiveness, coupled with improved metabolism will let the body blood circulation, The dark of skin is heavy can improve, capillary hole also can decrescent.

ITEMS SPECIFICATIONS TEST RESULTS
外観 Yellowish Crystalline Powder 準拠
識別(HPLC) Meets the requirements 準拠
融点 60~62℃ 61.7℃
溶解性(1N NaOH) Clear and Pale Yellow 準拠
Residune on Ingnition ≤0.10% 0.04%
ヘビーメタル ≤10ppm <10ppm
Chloride ≤0.10% <0.07%
Loss On Drying ≤0.20% 0. 06%
(Vacuum 40℃ 3hr)
アッセイ(HPLCによる,USP Method) 99.0~101.0% 99.36%
Specific Optical Rotation -1℃~+1℃ 準拠
Related Substance (HPLCによる)
単一の不純物 ≤0.10% 0.04%
6,8-Epitrithiooctanoic Acid ≤0.10% 0.01%
Total Impurities ≤0.50% 0.07%
Polymers (by TLC) ≤2.0% <2.0%
Residual Solvents (by GC)
Toluene ≤30ppm <20ppm
Cyclohexane ≤0.20% 0.07%
Microbiology
Total Aerobic Counts ≤1000CFU/g <100CFU/g
Mould & Yeast ≤100CFU/g <10CFU/g
E.coli Not Detectable Undetected
Salmonellas Not Detectable Undetected

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