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Active Pharmaceuticals

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Product Name Alpha Lipoic Acid Other name Alpha Lipoic Acid
CAS No. 62-46-4 M. F. C8H14O2S2
Purity 99%min M.W. 206.33
Appearance Slightly yellow crystal powder Grade USP

Lipoic acid is a coenzyme found in mitochondria that acts like a vitamin and neutralises free radicals that accelerate ageing and cause disease. Lipoic acid in the body through intestinal absorption into the cell, both fat soluble and water soluble characteristics, so it can pass through the whole body unimpeded, to reach any cell site, to provide comprehensive human performance, is a fat soluble and water soluble universal antioxidant. Lipoic acid acts as a coenzyme in two key oxidative decarboxylation reactions, Molecular structure diagram Molecular structure diagram In pyruvate dehydrogenase complex and α-ketoglutarate dehydrogenase complex, catalyze the production and transfer of acyl group. The lipoic acid can accept the acyl group to the acetyl group of pyruvate, form A thioester bond, and then transfer the acetyl group to the sulfur atom of the coenzyme A molecule. Dihydrothiooctam forming the auxiliary group can then be oxidized by dihydrothiooctam dehydrogenase (NAD required) to regenerate the oxidized thiooctam. α -lipoic acid contains disulfide five-member ring structure, high electron density, significant electrophilic and free radical reaction ability, so it has antioxidant, has high health care function and medical value (such as anti-fatty liver and reduce plasma cholesterol). In addition, the sulfhydryl group of lipoic acid is easy to REDOX reaction, so it can protect the sulfhydrase from heavy metal ions. Lipoic acid is widely distributed in nature, especially in liver and yeast cells. Lipoic acid is often present in foods together with vitamin B1. The human body can synthesize.

1. In the medical field: stabilize blood sugar, strengthen liver function, recover fatigue and improve dementia. Protect the body

2. In the field of beauty and cosmetics: Lipoic acid have amazing antioxidant ability, can remove skin aging caused by reactive oxygen species composition, and due to the smaller molecules than vitamin E, plus it is with water-soluble and fat-soluble, so skin is quite easy, especially for black rim of the eye, wrinkles and spots, such as effectiveness, coupled with improved metabolism will let the body blood circulation, The dark of skin is heavy can improve, capillary hole also can decrescent.

ITEMS SPECIFICATIONS TEST RESULTS
Appearance Yellowish Crystalline Powder Complies
Identification(HPLC) Meets the requirements Complies
Melting Point 60~62℃ 61.7℃
Solubility(1N NaOH) Clear and Pale Yellow Complies
Residune on Ingnition ≤0.10% 0.04%
Heavy Metals ≤10ppm <10ppm
Chloride ≤0.10% <0.07%
Loss On Drying ≤0.20% 0. 06%
(Vacuum 40℃ 3hr)
Assay(by HPLC,USP Method) 99.0~101.0% 99.36%
Specific Optical Rotation -1℃~+1℃ Complies
Related Substance (by HPLC)
Single Impurity ≤0.10% 0.04%
6,8-Epitrithiooctanoic Acid ≤0.10% 0.01%
Total Impurities ≤0.50% 0.07%
Polymers (by TLC) ≤2.0% <2.0%
Residual Solvents (by GC)
Toluene ≤30ppm <20ppm
Cyclohexane ≤0.20% 0.07%
Microbiology
Total Aerobic Counts ≤1000CFU/g <100CFU/g
Mould & Yeast ≤100CFU/g <10CFU/g
E.coli Not Detectable Undetected
Salmonellas Not Detectable Undetected

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