L-Triiodothyronine(T3)
CAS NO:6893-02-3
Chemical name:3,3′,5-Triiodo-L-thyronine, sodium salt
Molecular formula:C15H12I3NO4
Molecular Weight:650.97
Content:(%):99
Boiling point:205°C
Liothyronine is the most potent form of thyroid hormone. Chemically, it is nearly identical to triiodothyronine (T3). As such, it acts on the body to increase the basal metabolic rate, affect protein synthesis and increase the body's sensitivity to catecholamines (such as adrenaline) by permissiveness. The thyroid hormones are essential to proper development and differentiation of all cells of the human body. These hormones also regulate protein, fat, and carbohydrate metabolism, affecting how human cells use energetic compounds.
T3 is a regulator of the oxidative metabolism of energy. When you take liothyronine sodium it will increase the uptake of nutrients into the mitochondria, which raises activity in the oxidative metabolic pathway. This causes everything to work harder within the organism and makes the body demand more fuel.
Liothyronine is used to treat an underactive thyroid (hypothyroidism). It replaces or provides more thyroid hormone, which is normally made by the thyroid gland. Liothyronine is a man-made form of thyroid hormone.
Low thyroid hormone levels can occur naturally or when the thyroid gland is injured by radiation/medications or removed by surgery. Having enough thyroid hormone helps you stay healthy. For children, having enough thyroid hormone helps them grow and learn normally.
This medication is also used to treat other types of thyroid problems (such as certain types of goiters, thyroid cancer).
It can also be used to test for certain types of thyroid disease.This medication should not be used to treat infertility unless it is caused by low thyroid hormone levels.
| Item |
Specification |
Result |
| Appearance |
An odorless, almost white or buff colored powder |
pass |
| Solubility |
1,Very slightly soluble in water |
pass |
| 2,slightly soluble in alcohol |
pass |
| 3,practically insoluble in most other organic solvents |
pass |
| 4,disolves in diluted aqueous sodium hydroxide solutions |
Pass |
| Identification |
a) Heat about 50 mg with a few drops of sulfuric acid in a |
pass |
| porcelain crucible: violet vapors of iodine are evolved. |
| b)The retention time of the major peak is confirm to the RS |
pass |
| Loss on Drying |
Not more than 4.0% |
0.46% |
| [a]20/D |
+18 ~ +22o |
＋20.9o |
| C=1 in 1M HCl/EtOH 1:4 |
| Assay(HPLC) |
Not less than 95.0% |
99.18% |
| Levothyroxine sodium |
Not more than 5.0% |
0.68% |
| Conclusion: |
Up to the Standard for Export |
