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Local Anesthetic Drugs

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  • Product Description
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  • COA

Product Name: Lidocaine
Another Name: Xylocaine
CAS:137-58-6
MF:C14H22N2O
MW:234.34
Assay:99%
Appearance: White powder
Usage:can be used to relieve pain

Lidocaine, xylocaine, or lignocaine is a common local anesthetic and class-1b antiarrhythmic drug. Lidocaine is used topically to relieve itching, burning, and pain from skin inflammations, injected as a dental anesthetic, or as a local anesthetic for minor surgery.It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic healthcare system.

Lidocaine is the most important class-1b antiarrhythmic drug; it is used intravenously for the treatment of ventricular arrhythmias (for acute myocardial infarction, digoxin poisoning, cardioversion, or cardiac catheterization) if amiodarone is not available or contraindicated.

Lidocaine should be given for this indication after defibrillation, CPR, and vasopressors have been initiated. A routine prophylactic administration is no longer recommended for acute cardiac infarction; the overall benefit of this measure is not convincing.

The efficacy profile of lidocaine as a local anesthetic is characterized by a rapid onset of action and intermediate duration of efficacy. Therefore, lidocaine is suitable for infiltration, block, and surface anesthesia. Longer-acting substances such as bupivacaine are sometimes given preference for subdural and epidural anesthesias; lidocaine,though, has the advantage of a rapid onset of action.

Relative insensitivity to lidocaine is genetic.In hypokalemic sensory overstimulation, relative insensitivity to lidocaine has been described in people who also have attention deficit hyperactivity disorder.In dental anesthesia, a relative insensitivity to lidocaine can occur for anatomical reasons due to unexpected positions of nerves. Some people with Ehlers-Danlos syndrome are insensitive to lidocaine.

Lidocaine, along with ethanol, ammonia, and acetic acid, has also been proven to be effective in treating jellyfish stings, both numbing the affected area and preventing further nematocyst discharge.

Items Tested Specification BP2007 Result
Characters White or slightly yellow crystal powder with characteristic odor White crystal powder with weak odor
Melting point Melting point: 66 degree to 70 degree 66.6 degree-68.5 degree
Identification BCDE
Comply with the requirement
Conforms
Appearance of solution Clear and colorless Conforms
Water Not more than 0.5% 0.3%
Sulphate Not more than0. 1% Conforms
Chloride Not more than 0. 0035% 0.0025%
Heavy Metals Not more than 0.002% 0.001%
Residue on Ignition Not more than 0.1% 0.02%
Impurity
(26-dimethylaniline content)
Not more than 0.01% Conforms
Assay (HPLC) 99.0%-101.0% 99.50%

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