numele produsului: Goserelin
Sinonime: GOSERELIN ACETATE SALT;(D-SER(TBU)6,AZAGLY10)-GONADOTROPIN-RELEASING HORMONE ACETATE SALT;(D-SER(TBU)6,AZAGLY10)-LHRH ACETATE SALT;(D-SER(TBU)6,AZAGLY10)-LUTEINIZING HORMONE-RELEASING FACTOR ACETATE SALT;(D-SER(TBU)6,AZAGLY10)-LUTEINIZING HORMONE-RELEASING HORMONE ACETATE SALT;PYR-HIS-TRP-SER-TYR-D-SER(TBU)-LEU-ARG-PRO-AZAGLY-NH2 ACETATE SALT;2-(aminocarbonil)hydrazide;decapeptidei
CAS: 65807-02-5
MF: C61H88N18O16
MW: 1329.46
Goserelin is an analog of luteinizing hormone-releasing hormone (LHRH) useful in the treatment of malignancies responsive to hormonal manipulation. Administered parenterally in a biodegradable depot, goserelin is reportedly as effective as orchidectomy and oophorectomy in patients with advanced prostate carcinoma and pre-menopausal breast cancer.
1. Gonadorelin este un alt nume pentru hormonul care eliberează gonadotropină (Gnrh). Este o decapeptidă sintetică preparată folosind sinteza peptidelor cu fază solidă. GnRH is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary.
2. GnRH este disponibil ca clorhidrat de gonadorelin )și tetrahidrat diacetat de gonadoreline pentru utilizare injectabilă. Studies have described it being used via an infusion pump system to induce ovulation in patients with hypothalamic hypogonadism. De asemenea, este utilizat în medicina veterinară ca tratament pentru bovinele cu boală ovariană chistică.
3. Gonadorelin is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary. In the pituitary GnRH stimulates synthesis and release of FSH and LH, a process that is controlled by the frequency and amplitude of GnRH pulses, as well as the feedback of androgens and estrogens.
Bărbați
Palliative treatment of advanced carcinoma of the prostate; in combination with flutamide for management of locally confined stage T2b to T4 (stage B2 to C) carcinoma of the prostate.
femei (3.6 mg only)
Palliative treatment of advanced breast cancer in pre- and perimenopausal women; treatment of endometriosis; as an endometrial thinning agent prior to endometrial ablation for dysfunctional uterine bleeding.
