Name:Ganirelix acetate
Type:GMP peptides
Sequence:Ac-D-2-Nal-D-4-ClPhe-D-3-Pal-Ser-Tyr-D-Lys(C(NHEt)
CAS.NO:123246-29-7
Single Impurity(HPLC):1.0%
Peptide Content(N%):80%(by %N)
Acid content(HPLC):15.0%
Mass balance:95.0~105.0%
MW :1570.4
Formula :C80H113N18O13Cl
Purity(HPLC):98.0%
Appearance:White powder
Amino Acid Composition:10% of theetical
Water content(Karl Fischer):6.0%
Ganirelix is a synthetic decapeptide compound. Its acetate, Ganirelix Acetate, releasing hormone (GnRH) receptor antagonist. The amino acid sequence is: Ac-D-2Nal-D-4Cpa-D-3Pal-Ser-Tyr-D-HoChemicalbookmoArg(9,10-Et2)-Leu-L-HomoArg(9,10-Et2)-Pro-D- Ala-NH2. Clinically, it is mainly used in women receiving assisted reproductive technology in controlled ovarian stimulation programs to prevent premature lutei nizing hormone peaks and to treat fertility disorders caused by this reason.
Ganirelix should not be used in women who are already pregnant, and because of this the onset of pregnancy must be ruled out before it is administered. Women using ganirelix should not breast feed, as it is not known whether ganirelix is excreted in breast milk.
